AKIRIN2 - akirin 2 Gene

Also Known as FBI1; C6orf166; dJ486L4.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55122

About AKIRIN2

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:87,674,860-87,702,233 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 25.3), spleen (RPKM 21.1) and 24 other tissues.

Summary

Enables enzyme binding activity and identical protein binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of interleukin-6 production and response to lipopolysaccharide. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AKIRIN2 Products (1)

mRNA Protein Name
NM_018064.4 NP_060534.1 akirin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
34711951 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of positive effect nuclear protein quality control by the ubiquitin-proteasome system IDA
IDA: Inferred from direct assay
34711951 GOA
involved in proteasome localization IDA
IDA: Inferred from direct assay
34711951 GOA
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
34711951 GOA
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
34711951 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18066067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

akirin-2

  • fourteen-three-three beta interactant 1

AKIRIN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AKIRIN2 Q53H80 MYOZ3 Homo sapiens Q8TDC0
Validated Y2H
32296183
Intra
AKIRIN2 Q53H80 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
AKIRIN2 Q53H80 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra
AKIRIN2 Q53H80 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
AKIRIN2 Q53H80 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
AKIRIN2 Q53H80 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
AKIRIN2 Q53H80 HSD17B14 Homo sapiens Q9BPX1
Y2H Prey Pooling
32296183
Intra
AKIRIN2 Q53H80 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
32296183
Intra
AKIRIN2 Q53H80 HSD17B14 Homo sapiens Q9BPX1
Y2H Array
32296183
Intra
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Anti Tag CoIP
33961781
Intra
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Anti Tag CoIP
28514442
Intra
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Y2H Array
32296183
Intra
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
32296183
Intra
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Y2H Array
31515488
Intra
AKIRIN2 Q53H80 AKIRIN2 Homo sapiens Q53H80
Validated Y2H
32296183
Intra
AKIRIN2 Q53H80 AKIRIN2 Homo sapiens Q53H80
Y2H Array
32296183
Intra
AKIRIN2 Q53H80 AKIRIN2 Homo sapiens Q53H80
Y2H Prey Pooling
32296183
Intra
AKIRIN2 Q53H80 RAN Homo sapiens P62826
Anti Tag CoIP
28514442
Intra
AKIRIN2 Q53H80 RAN Homo sapiens P62826
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Zebrafish Allergy

  • Danio Rerio Allergy
Tick Infestation

  • Tick Infestations
Metacarpal 4-5 Fusion

  • Syndactyly Type 8

  • MF4

  • Fusion Of Metacarpals 4 And 5

  • Metacarpals 4 And 5 Fusion

  • Metacarpal 4 5 Fusion
Parasitic Ectoparasitic Infectious Disease

  • Ectoparasitic Infestations

  • Ectoparasitism
Lice Infestation

  • Pediculosis

  • Louse Infestation

  • Mixed Pediculosis

  • Lice Infestations

  • Infestation By Pediculus

  • Mixed Pediculosis Infestation

  • Pediculosis + Lice

  • Pediculosis And Phthirus Infection

  • Pediculosis And Phthirus Infections

  • Pediculosis And Phthirus Infestation

  • Infestation By Anoplura

  • Pediculus Infestation

  • Lice Nos
Tick Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00528 AKIRIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AKIRIN2 VGNC VGNC:25794
Mus musculus AKIRIN2 MGD MGI:1889364
Canis familiaris AKIRIN2 VGNC VGNC:37766
Felis catus AKIRIN2 VGNC VGNC:59721
Rattus norvegicus AKIRIN2 RGD RGD:1307791
Macaca mulatta AKIRIN2 VGNC VGNC:69665
Others AKIRIN2 NCBI