CYP4F11 - cytochrome P450 family 4 subfamily F member 11 Gene

Also Known as CYPIVF11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57834

About CYP4F11

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,912,377-15,934,867 (from NCBI)

This gene has 5 transcripts (splice variants), 381 orthologues and 12 paralogues. Biased expression in liver (RPKM 19.6), gall bladder (RPKM 11.3) and 11 other tissues.

Summary

This gene, CYP4F11, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CYP4F11 Products (2)

mRNA Protein Name
NM_001128932.2 NP_001122404.1 cytochrome P450 4F11 precursor
NM_021187.4 NP_067010.3 cytochrome P450 4F11 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables fatty acid binding IDA
IDA: Inferred from direct assay
18065749 GOA
enables long-chain fatty acid omega-hydroxylase activity IDA
IDA: Inferred from direct assay
15364545 GOA
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
18065749 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in fatty acid metabolic process IDA
IDA: Inferred from direct assay
18065749 GOA
involved in menaquinone catabolic process IDA
IDA: Inferred from direct assay
24138531 GOA
involved in omega-hydroxylase P450 pathway IDA
IDA: Inferred from direct assay
15364545 GOA
involved in phylloquinone catabolic process IDA
IDA: Inferred from direct assay
24138531 GOA
involved in vitamin K catabolic process IDA
IDA: Inferred from direct assay
24138531 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4F11 Protein Structure

p450

p450: Cytochrome P450 (52 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 524 a.a.
Protein Preferred Names Protein Names

cytochrome P450 4F11

  • 3-hydroxy fatty acids omega-hydroxylase CYP4F11

CYP4F11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CYP4F11 Q9HBI6 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
CYP4F11 Q9HBI6 MESD Homo sapiens Q14696
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bietti Crystalline Corneoretinal Dystrophy

  • BCD

  • Bietti Crystalline Dystrophy

  • Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy

  • Bietti Crystalline Retinopathy

  • Bietti'S Crystalline Dystrophy

  • Crystalline Retinopathy

  • Dystrophy, Corneoretinal, Crystalline, Bietti
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-124084A SW203668 TFA Inhibitor 99.79% Unkown
HY-124084 SW203668 Inhibitor / Unkown
HY-RS03478 CYP4F11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYP4F11 RGD RGD:1559596
Macaca mulatta CYP4F11 VGNC VGNC:103612
Others CYP4F11 NCBI