Ap5z1 - adaptor-related protein complex 5, zeta 1 subunit Gene

Mus musculus

Also known as C330006K01Rik

Gene ID: 231855 | Gene type: protein coding

About Ap5z1

Summary

Predicted to be involved in double-strand break repair via homologous recombination and endosomal transport. Predicted to act upstream of or within DNA repair and protein transport. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of AP-5 adaptor complex. Used to study hereditary spastic paraplegia 48. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia and hereditary spastic paraplegia 48. Orthologous to human AP5Z1 (adaptor related protein complex 5 subunit zeta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap5z1 Products(1)

mRNA	Protein	Name
NM_172725.2	NP_766313.2	AP-5 complex subunit zeta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	37871017	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Golgi organization	IMP IMP: Inferred from mutant phenotype	30930081	MGI
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	30930081	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	30930081	MGI
acts upstream of or within axon development	IMP IMP: Inferred from mutant phenotype	30930081	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	37871017	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	37871017	MGI
acts upstream of or within late endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	30930081	MGI
acts upstream of or within lysosomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	30930081	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	37871017	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in lysosome	IMP IMP: Inferred from mutant phenotype	37871017	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

AP-5 complex subunit zeta-1

adapter-related protein complex 5 zeta subunit	adaptor-related protein complex 5 zeta subunit
zeta5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00800	AP5Z1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ap5z1	NCBI	NCBI:9907

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