DTX4 - deltex E3 ubiquitin ligase 4 Gene

Homo sapiens

Also known as RNF155

Gene ID: 23220 | Gene type: protein coding

About DTX4

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,171,430-59,208,588 (from NCBI)

This gene has 4 transcripts (splice variants), 284 orthologues and 4 paralogues. Ubiquitous expression in urinary bladder (RPKM 13.0), lung (RPKM 11.7) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in Notch signaling pathway and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DTX4 Products(2)

mRNA	Protein	Name
NM_001300727.2	NP_001287656.1	E3 ubiquitin-protein ligase DTX4 isoform 2
NM_015177.2	NP_055992.1	E3 ubiquitin-protein ligase DTX4 isoform 1

DTX4 Protein Structure

WWE

zf-RING_2

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase DTX4

RING finger protein 155

Related Diseases

Diseases

Alias

Cutaneous Diphtheria

Diphtheria Wound Infection

Congenital Anomalies Of Kidney And Urinary Tract 2

CAKUT2	Ureteropelvic Junction Obstruction
Multicystic Renal Dysplasia, Bilateral	Pelviureteric Junction Obstruction
Pujo	Hydronephrosis Due To Pujo
Upjo	Mcrd
Congenital Anomalies Of The Kidney And Urinary Tract 2	Mrd
Pelvi-Ureteric Junction Obstruction	Kidney And Urinary Tract, Anomalies, Congenital, Type 2
Obstruction Of Pelviureteric Junction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04042	DTX4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DTX4	MGD	MGI:2672905
Felis catus	DTX4	VGNC	VGNC:102876
Rattus norvegicus	DTX4	RGD	RGD:1311767
Canis familiaris	DTX4	VGNC	VGNC:40119
Bos taurus	DTX4	VGNC	VGNC:54867
Macaca mulatta	DTX4	VGNC	VGNC:71929