DTX4 - deltex E3 ubiquitin ligase 4 Gene

Also Known as RNF155

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23220

About DTX4

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,171,430-59,208,588 (from NCBI)

This gene has 4 transcripts (splice variants), 284 orthologues and 4 paralogues. Ubiquitous expression in urinary bladder (RPKM 13.0), lung (RPKM 11.7) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in Notch signaling pathway and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DTX4 Products (2)

mRNA Protein Name
NM_001300727.2 NP_001287656.1 E3 ubiquitin-protein ligase DTX4 isoform 2
NM_015177.2 NP_055992.1 E3 ubiquitin-protein ligase DTX4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
35793002 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of innate immune response IDA
IDA: Inferred from direct assay
27692986 GOA
involved in proteasomal protein catabolic process IDA
IDA: Inferred from direct assay
35793002 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
27692986 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
27692986 GOA
Cellular Component GO Annotation Evidence References Source
is active in centrosome IDA
IDA: Inferred from direct assay
35793002 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTX4 Protein Structure

WWE

WWE: WWE domain (3 - 78)

WWE

WWE: WWE domain (85 - 155)

zf-RING_2

zf-RING_2: Ring finger domain (408 - 468)

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  • 619 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase DTX4

  • RING finger protein 155

Related Diseases

Diseases Alias
Cutaneous Diphtheria

  • Diphtheria Wound Infection
Congenital Anomalies Of Kidney And Urinary Tract 2

  • CAKUT2

  • Ureteropelvic Junction Obstruction

  • Multicystic Renal Dysplasia, Bilateral

  • Pelviureteric Junction Obstruction

  • Pujo

  • Hydronephrosis Due To Pujo

  • Upjo

  • Mcrd

  • Congenital Anomalies Of The Kidney And Urinary Tract 2

  • Mrd

  • Pelvi-Ureteric Junction Obstruction

  • Kidney And Urinary Tract, Anomalies, Congenital, Type 2

  • Obstruction Of Pelviureteric Junction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04042 DTX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21330 Dtx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27849 Dtx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DTX4 MGD MGI:2672905
Felis catus DTX4 VGNC VGNC:102876
Rattus norvegicus DTX4 RGD RGD:1311767
Canis familiaris DTX4 VGNC VGNC:40119
Bos taurus DTX4 VGNC VGNC:54867
Macaca mulatta DTX4 VGNC VGNC:71929
Others DTX4 NCBI