Iqsec1 - IQ motif and Sec7 domain 1 Gene

Also Known as BRAG2; cI-43; D6Ertd349e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232227

Summary

Enables protein kinase binding activity. Involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Located in Schaffer collateral - CA1 synapse. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in central nervous system; forelimb muscle; sensory organ; and viscerocranium. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Apr 2022]

Iqsec1 Products (19)

mRNA Protein Name
NM_001134383.2 NP_001127855.1 IQ motif and SEC7 domain-containing protein 1 isoform a
NM_001134384.2 NP_001127856.1 IQ motif and SEC7 domain-containing protein 1 isoform b
NM_001356440.2 NP_001343369.1 IQ motif and SEC7 domain-containing protein 1 isoform c
NM_001408942.1 NP_001395871.1 IQ motif and SEC7 domain-containing protein 1 isoform d
NM_001408943.1 NP_001395872.1 IQ motif and SEC7 domain-containing protein 1 isoform e
NM_001408944.1 NP_001395873.1 IQ motif and SEC7 domain-containing protein 1 isoform f
NM_001408946.1 NP_001395875.1 IQ motif and SEC7 domain-containing protein 1 isoform g
NM_001408947.1 NP_001395876.1 IQ motif and SEC7 domain-containing protein 1 isoform h
NM_001408948.1 NP_001395877.1 IQ motif and SEC7 domain-containing protein 1 isoform h
NM_001408949.1 NP_001395878.1 IQ motif and SEC7 domain-containing protein 1 isoform i
NM_001408950.1 NP_001395879.1 IQ motif and SEC7 domain-containing protein 1 isoform j
NM_001408951.1 NP_001395880.1 IQ motif and SEC7 domain-containing protein 1 isoform k
NM_001408952.1 NP_001395881.1 IQ motif and SEC7 domain-containing protein 1 isoform l
NM_001408953.1 NP_001395882.1 IQ motif and SEC7 domain-containing protein 1 isoform m
NM_001408954.1 NP_001395883.1 IQ motif and SEC7 domain-containing protein 1 isoform n
NM_001408955.1 NP_001395884.1 IQ motif and SEC7 domain-containing protein 1 isoform o
NM_001408956.1 NP_001395885.1 IQ motif and SEC7 domain-containing protein 1 isoform p
NM_001408957.1 NP_001395886.1 IQ motif and SEC7 domain-containing protein 1 isoform p
NM_001408958.1 NP_001395887.1 IQ motif and SEC7 domain-containing protein 1 isoform p

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25490267 MGI
Biological Process GO Annotation Evidence References Source
involved in dendritic spine development IMP
IMP: Inferred from mutant phenotype
31607425 MGI
involved in positive regulation of focal adhesion disassembly IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
20547133 MGI
involved in postsynaptic modulation of chemical synaptic transmission IEP
IEP: Inferred from expression pattern
20547133 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
20547133 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
20547133 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
20547133 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
20547133 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
20547133 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: Inferred from expression pattern
20547133 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
20547133 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22886754 MGI
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
22886754 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

IQ motif and SEC7 domain-containing protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06888 IQSEC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Iqsec1 NCBI NCBI:9922