Ankrd26 - ankyrin repeat domain 26 Gene

Mus musculus

Also known as mKIAA1074; 5730521P14Rik

Gene ID: 232339 | Gene type: protein coding

About Ankrd26

Summary

Involved in negative regulation of fat cell differentiation. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of organ growth; and negative regulation of signal transduction. Located in actin Cytoskeleton. Used to study obesity. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including ANKRD26 (ankyrin repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]

Ankrd26 Products(1)

mRNA	Protein	Name
NM_001081112.2	NP_001074581.1	ankyrin repeat domain-containing protein 26

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21689717	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21669876	MGI
acts upstream of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	21669876	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	21842266	MGI
acts upstream of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21842266	MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21669876	MGI
acts upstream of or within negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	21669876	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	22666460	MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21842266	MGI
acts upstream of or within negative regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	18162531	MGI
acts upstream of or within negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	18162531	MGI
acts upstream of organ growth	IMP IMP: Inferred from mutant phenotype	18162531	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	18162531	MGI
acts upstream of or within regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	18162531	MGI
acts upstream of or within regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	18162531	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	18162531	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ankyrin repeat domain-containing protein 26

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00719	ANKRD26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ankrd26	NCBI	NCBI:22852

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