CLEC16A - C-type lectin domain containing 16A Gene

Also Known as Gop-1; KIAA0350

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23274

About CLEC16A

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:10,944,564-11,182,186 (from NCBI)

This gene has 14 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 11.3), brain (RPKM 3.5) and 24 other tissues.

Summary

This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

CLEC16A Products (3)

mRNA Protein Name
NM_001243403.2 NP_001230332.1 protein CLEC16A isoform 2
NM_001410905.1 NP_001397834.1 protein CLEC16A isoform 3
NM_015226.3 NP_056041.1 protein CLEC16A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
36538041 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to starvation IMP
IMP: Inferred from mutant phenotype
28223137 GOA
involved in mitophagy IDA
IDA: Inferred from direct assay
35604110 GOA
involved in negative regulation of autophagosome maturation IMP
IMP: Inferred from mutant phenotype
28223137 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
28223137 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
28223137 GOA
located in cytosol IDA
IDA: Inferred from direct assay
28223137 GOA
located in vesicle IDA
IDA: Inferred from direct assay
28223137 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC16A Protein Structure

FPL

FPL: Uncharacterised conserved protein (51 - 199)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1053 a.a.
Protein Preferred Names Protein Names

protein CLEC16A

  • C-type lectin domain family 16 member A

Related Diseases

Diseases Alias
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Immunoglobulin A Deficiency 1

  • Immunoglobulin A Deficiency

  • Selective Iga Deficiency Disease

  • Selective Immunoglobulin A Deficiency

  • IGAD1

  • Immunoglobulin A, Selective Deficiency Of

  • Iga, Selective Deficiency Of

  • Gamma-A-Globulin, Selective Deficiency Of

  • Selective Iga Immunodeficiency

  • Selective Iga Deficiency

  • Iga Deficiency Selective
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Selective Immunoglobulin Deficiency Disease
Alopecia Areata

  • Aa

  • Alopecia Celsi

  • Alopecia Circumscripta

  • Cazenave'S Vitiligo

  • Celsus' Vitiligo

  • Diffuse Alopecia

  • Jonston'S Alopecia

  • Marginal Alopecia

  • Pseudopelade

  • Circumscribed Alopecia

  • Alopecia Cicatrisata

  • Patchy Alopecia

  • Alopecia

  • Aa - [Alopecia Areata]

  • Pelade
Diabetes Mellitus

  • Diabetes
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Dysgammaglobulinemia
Common Variable Immunodeficiency

  • Cvid

  • Common Variable Agammaglobulinemia

  • Common Variable Immune Deficiency

  • Acquired Hypogammaglobulinemia

  • Hypogamma-Globulinemia, Acquired

  • Idiopathic Immunoglobulin Deficiency

  • Primary Antibody Deficiency

  • Primary Hypogammaglobulinemia

  • Acquired Agammaglobulinemia

  • Sporadic Hypogammaglobulinemia

  • Common Variable Hypogamma-Globulinemia

  • Immunoglobulin Deficiency, Late-Onset

  • Common Variable Hypogammaglobulinemia

  • Immunodeficiency, Common Variable
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02784 CLEC16A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLEC16A VGNC VGNC:39328
Bos taurus CLEC16A VGNC VGNC:27426
Felis catus CLEC16A VGNC VGNC:60944
Macaca mulatta CLEC16A VGNC VGNC:71369
Rattus norvegicus CLEC16A RGD RGD:1305773
Mus musculus CLEC16A MGD MGI:1921624
Others CLEC16A NCBI