Shisa7 - shisa family member 7 Gene

Also Known as ckamp59

Species: Mus musculus

Gene Type: protein coding

Gene ID: 232813

Summary

Enables GABA Receptor binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Is integral component of postsynaptic specialization membrane. Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; rib; and tail mesenchyme. Orthologous to human SHISA7 (shisa family member 7). [provided by Alliance of Genome Resources, Apr 2022]

Shisa7 Products (2)

mRNA	Protein	Name
NM_001290291.1	NP_001277220.1	protein shisa-7 isoform 2 precursor
NM_172737.4	NP_766325.3	protein shisa-7 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GABA receptor binding	IDA IDA: Inferred from direct assay	31601770	MGI
NOT enables ionotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	31601770	MGI
enables ionotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	29199957	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	29199957	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in gamma-aminobutyric acid receptor clustering	IDA IDA: Inferred from direct assay	31601770	MGI
involved in gamma-aminobutyric acid signaling pathway	IDA IDA: Inferred from direct assay	31601770	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	29199957	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	29199957	MGI
NOT involved in regulation of AMPA glutamate receptor clustering	IDA IDA: Inferred from direct assay	31601770	MGI
involved in regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	29199957	MGI
NOT involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	31601770	MGI
involved in regulation of GABA-A receptor activity	IDA IDA: Inferred from direct assay	31601770	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	29199957	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IMP IMP: Inferred from mutant phenotype	29199957	MGI

Cellular Component GO Annotation	Evidence	References	Source
NOT part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	31601770	MGI
NOT located in asymmetric, glutamatergic, excitatory synapse	IDA IDA: Inferred from direct assay	31601770	MGI
located in asymmetric, glutamatergic, excitatory synapse	IDA IDA: Inferred from direct assay	29199957	MGI
NOT located in glutamatergic synapse	IDA IDA: Inferred from direct assay	31601770	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29199957	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	29199957	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	29199957	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	29199957	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	29199957	MGI
is active in postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	29199957	MGI
is active in postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	29199957	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein shisa-7	GABA(A) receptor auxiliary subunit Shisa7 cysteine-knot AMPAR-modulating protein 59 cystine-knot AMPAR modulating protein of 59 kDa shisa homolog 7

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12870	SHISA7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shisa7	NCBI	NCBI:729956