ADGRL3 - adhesion G protein-coupled receptor L3 Gene

Also Known as CL3; LEC3; CIRL3; LPHN3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23284

About ADGRL3

Cytogenetic location: 4q13.1 Genomic coordinates (GRCh38): 4:61,200,326-62,078,335 (from NCBI)

This gene has 19 transcripts (splice variants), 211 orthologues and 42 paralogues. Biased expression in brain (RPKM 7.2), adrenal (RPKM 1.9) and 13 other tissues.

Summary

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/Calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

ADGRL3 Products (37)

mRNA Protein Name
NM_001322246.3 NP_001309175.1 adhesion G protein-coupled receptor L3 isoform 3 precursor
NM_001322402.3 NP_001309331.1 adhesion G protein-coupled receptor L3 isoform 1 precursor
NM_001371342.1 NP_001358271.1 adhesion G protein-coupled receptor L3 isoform 4 precursor
NM_001371343.2 NP_001358272.1 adhesion G protein-coupled receptor L3 isoform 5 precursor
NM_001371344.2 NP_001358273.1 adhesion G protein-coupled receptor L3 isoform 6 precursor
NM_001371345.2 NP_001358274.1 adhesion G protein-coupled receptor L3 isoform 7 precursor
NM_001371346.2 NP_001358275.1 adhesion G protein-coupled receptor L3 isoform 8 precursor
NM_001387522.1 NP_001374451.1 adhesion G protein-coupled receptor L3 isoform 6 precursor
NM_001387523.1 NP_001374452.1 adhesion G protein-coupled receptor L3 isoform 9 precursor
NM_001387524.1 NP_001374453.1 adhesion G protein-coupled receptor L3 isoform 25 precursor
NM_001387525.1 NP_001374454.1 adhesion G protein-coupled receptor L3 isoform 5 precursor
NM_001387526.1 NP_001374455.1 adhesion G protein-coupled receptor L3 isoform 10 precursor
NM_001387527.1 NP_001374456.1 adhesion G protein-coupled receptor L3 isoform 11 precursor
NM_001387528.1 NP_001374457.1 adhesion G protein-coupled receptor L3 isoform 26 precursor
NM_001387529.1 NP_001374458.1 adhesion G protein-coupled receptor L3 isoform 2 precursor
NM_001387530.1 NP_001374459.1 adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_001387531.1 NP_001374460.1 adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_001387532.1 NP_001374461.1 adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_001387533.1 NP_001374462.1 adhesion G protein-coupled receptor L3 isoform 13 precursor
NM_001387534.1 NP_001374463.1 adhesion G protein-coupled receptor L3 isoform 13 precursor
NM_001387535.1 NP_001374464.1 adhesion G protein-coupled receptor L3 isoform 14 precursor
NM_001387536.1 NP_001374465.1 adhesion G protein-coupled receptor L3 isoform 14 precursor
NM_001387537.1 NP_001374466.1 adhesion G protein-coupled receptor L3 isoform 15 precursor
NM_001387538.1 NP_001374467.1 adhesion G protein-coupled receptor L3 isoform 15 precursor
NM_001387539.1 NP_001374468.1 adhesion G protein-coupled receptor L3 isoform 15 precursor
NM_001387540.1 NP_001374469.1 adhesion G protein-coupled receptor L3 isoform 24 precursor
NM_001387541.1 NP_001374470.1 adhesion G protein-coupled receptor L3 isoform 16
NM_001387542.1 NP_001374471.1 adhesion G protein-coupled receptor L3 isoform 17 precursor
NM_001387543.1 NP_001374472.1 adhesion G protein-coupled receptor L3 isoform 18
NM_001387544.1 NP_001374473.1 adhesion G protein-coupled receptor L3 isoform 18
NM_001387545.1 NP_001374474.1 adhesion G protein-coupled receptor L3 isoform 19 precursor
NM_001387546.1 NP_001374475.1 adhesion G protein-coupled receptor L3 isoform 20 precursor
NM_001387547.1 NP_001374476.1 adhesion G protein-coupled receptor L3 isoform 3 precursor
NM_001387548.1 NP_001374477.1 adhesion G protein-coupled receptor L3 isoform 21 precursor
NM_001387549.1 NP_001374478.1 adhesion G protein-coupled receptor L3 isoform 22 precursor
NM_001387552.1 NP_001374481.1 adhesion G protein-coupled receptor L3 isoform 23 precursor
NM_015236.7 NP_056051.2 adhesion G protein-coupled receptor L3 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
26235030 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26235030 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: Inferred from direct assay
26235030 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
26235030 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRL3 Protein Structure

Gal_Lectin

Gal_Lectin: Galactose binding lectin domain (43 - 123)

OLF

OLF: Olfactomedin-like domain (139 - 392)

HRM

HRM: Hormone receptor domain (496 - 552)

(559 - 789)

GPS

GPS: GPCR proteolysis site, GPS, motif (815 - 861)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (876 - 1119)

Latrophilin

Latrophilin: Latrophilin Cytoplasmic C-terminal region (1139 - 1204)

Latrophilin

Latrophilin: Latrophilin Cytoplasmic C-terminal region (1205 - 1469)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1469 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor L3

  • calcium-independent alpha-latrotoxin receptor 3

Related Diseases

Diseases Alias
Sialuria

  • Sialuria, French Type

  • French Type Sialuria

  • Sialuria French Type

  • Sialic Acid Storage Disease

  • Sialic Acid Storage Disease, Finnish Type

  • Infantile Sialic Acid Storage Disease
Oppositional Defiant Disorder

  • Disorder

  • Oppositional Defiance

  • Behavioural Disorder

  • Oppositional Defiance

  • Disruptive Mood Dysregulation Disorder
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00363 ADGRL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADGRL3 VGNC VGNC:37652
Felis catus ADGRL3 VGNC VGNC:78449
Mus musculus ADGRL3 MGD MGI:2441950
Rattus norvegicus ADGRL3 RGD RGD:620836
Bos taurus ADGRL3 VGNC VGNC:53686
Macaca mulatta ADGRL3 VGNC VGNC:69659
Others ADGRL3 NCBI