Atp1a3 - ATPase, Na+/K+ transporting, alpha 3 polypeptide Gene

Also Known as Atpa-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232975

Summary

Enables P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential and heparan sulfate proteoglycan binding activity. Involved in several processes, including cellular sodium ion homeostasis; regulation of cardiac muscle cell membrane potential; and sodium ion export across plasma membrane. Acts upstream of or within several processes, including adult locomotory behavior; ionotropic glutamate receptor signaling pathway; and learning or memory. Located in several cellular components, including neuron to neuron synapse; photoreceptor inner segment; and sarcolemma. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including alimentary system; early conceptus; gonad; heart; and nervous system. Used to study alternating hemiplegia of childhood and bipolar disorder. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a3 Products (2)

mRNA Protein Name
NM_001290469.1 NP_001277398.1 sodium/potassium-transporting ATPase subunit alpha-3 isoform 2
NM_001374627.1 NP_001361556.1 sodium/potassium-transporting ATPase subunit alpha-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables P-type sodium:potassium-exchanging transporter activity IDA
IDA: Inferred from direct assay
19666602 MGI
enables P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential IGI
IGI: Inferred from genetic interaction
19376779 MGI
enables heparan sulfate proteoglycan binding IPI
IPI: Inferred from physical interaction
19376779 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22025725 MGI
acts upstream of or within L-ascorbic acid metabolic process IGI
IGI: Inferred from genetic interaction
33544780 MGI
acts upstream of or within L-ascorbic acid metabolic process IMP
IMP: Inferred from mutant phenotype
33544780 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
17234593 MGI
acts upstream of or within behavior IGI
IGI: Inferred from genetic interaction
22520507 MGI
acts upstream of or within behavior IMP
IMP: Inferred from mutant phenotype
21418141 MGI
acts upstream of or within blood circulation IGI
IGI: Inferred from genetic interaction
33544780 MGI
acts upstream of or within brain-derived neurotrophic factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24342563 MGI
acts upstream of or within calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
22025725 MGI
acts upstream of or within carboxylic acid transport IMP
IMP: Inferred from mutant phenotype
33544780 MGI
involved in cardiac muscle contraction IDA
IDA: Inferred from direct assay
19376779 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
23527305 MGI
acts upstream of or within circadian rhythm IGI
IGI: Inferred from genetic interaction
22520507 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
23527305 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
30071271 MGI
acts upstream of or within fear response IDA
IDA: Inferred from direct assay
26463346 MGI
acts upstream of or within fear response IMP
IMP: Inferred from mutant phenotype
26463346 MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway IMP
IMP: Inferred from mutant phenotype
27549929 MGI
acts upstream of or within habituation IMP
IMP: Inferred from mutant phenotype
26501181 MGI
involved in intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
19376779 MGI
acts upstream of or within ionotropic glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17234593 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within locomotion IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
26501181 MGI
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
30819023 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
17234593 MGI
acts upstream of or within metabolic process IMP
IMP: Inferred from mutant phenotype
23527305 MGI
acts upstream of or within motor behavior IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within multicellular organism growth IDA
IDA: Inferred from direct assay
26463346 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
26463346 MGI
acts upstream of or within neurogenesis IDA
IDA: Inferred from direct assay
19666602 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
19666602 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
25523819 MGI
acts upstream of or within neuromuscular process controlling balance IDA
IDA: Inferred from direct assay
26463346 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
22025725 MGI
acts upstream of or within pore complex assembly IMP
IMP: Inferred from mutant phenotype
23527305 MGI
involved in regulation of cardiac muscle cell membrane potential IGI
IGI: Inferred from genetic interaction
19376779 MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
25523819 MGI
acts upstream of or within response to acid chemical IMP
IMP: Inferred from mutant phenotype
22025725 MGI
acts upstream of or within response to activity IMP
IMP: Inferred from mutant phenotype
24342563 MGI
acts upstream of or within response to chemical IMP
IMP: Inferred from mutant phenotype
25523819 MGI
acts upstream of or within response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
25523819 MGI
acts upstream of or within response to environmental enrichment IMP
IMP: Inferred from mutant phenotype
26501181 MGI
acts upstream of or within response to hormone IMP
IMP: Inferred from mutant phenotype
24342563 MGI
acts upstream of or within response to immobilization stress IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within response to lithium ion IMP
IMP: Inferred from mutant phenotype
22025725 MGI
acts upstream of or within response to methamphetamine hydrochloride IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within response to monoamine IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within response to potassium ion IMP
IMP: Inferred from mutant phenotype
25523819 MGI
acts upstream of or within response to stress IMP
IMP: Inferred from mutant phenotype
21418141 MGI
acts upstream of or within response to temperature stimulus IMP
IMP: Inferred from mutant phenotype
20850480 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
17234593 MGI
acts upstream of or within sleep IMP
IMP: Inferred from mutant phenotype
24342563 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
26501181 MGI
involved in sodium ion export across plasma membrane IDA
IDA: Inferred from direct assay
19376779 MGI
acts upstream of or within thalamus development IMP
IMP: Inferred from mutant phenotype
23527305 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
19666602 MGI
acts upstream of or within visual learning IDA
IDA: Inferred from direct assay
26463346 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
17234593 MGI
acts upstream of or within walking behavior IMP
IMP: Inferred from mutant phenotype
25523819 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell surface IDA
IDA: Inferred from direct assay
17804407 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10837135 MGI
located in neuron to neuron synapse IDA
IDA: Inferred from direct assay
21196491 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10837135 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
21196491 MGI
NOT located in plasma membrane IDA
IDA: Inferred from direct assay
10837135 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17804407 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
19376779 MGI
part of sodium:potassium-exchanging ATPase complex IDA
IDA: Inferred from direct assay
19376779 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/potassium-transporting ATPase subunit alpha-3

  • Na(+)/K(+) ATPase alpha(III) subunit

  • Na(+)/K(+) ATPase alpha-3 subunit

  • sodium pump subunit alpha-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01188 ATP1B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01184 ATP1A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp1a3 NCBI NCBI:478