Atp1a3 - ATPase, Na+/K+ transporting, alpha 3 polypeptide Gene

Mus musculus

Also known as Atpa-2

Gene ID: 232975 | Gene type: protein coding

About Atp1a3

Summary

Enables P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential and heparan sulfate proteoglycan binding activity. Involved in several processes, including cellular sodium ion homeostasis; regulation of cardiac muscle cell membrane potential; and sodium ion export across plasma membrane. Acts upstream of or within several processes, including adult locomotory behavior; ionotropic glutamate receptor signaling pathway; and learning or memory. Located in several cellular components, including neuron to neuron synapse; photoreceptor inner segment; and sarcolemma. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including alimentary system; early conceptus; gonad; heart; and nervous system. Used to study alternating hemiplegia of childhood and bipolar disorder. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a3 Products(2)

mRNA	Protein	Name
NM_001290469.1	NP_001277398.1	sodium/potassium-transporting ATPase subunit alpha-3 isoform 2
NM_001374627.1	NP_001361556.1	sodium/potassium-transporting ATPase subunit alpha-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	19666602	MGI
enables P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential	IGI IGI: Inferred from genetic interaction	19376779	MGI
enables heparan sulfate proteoglycan binding	IPI IPI: Inferred from physical interaction	19376779	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22025725	MGI
acts upstream of or within L-ascorbic acid metabolic process	IGI IGI: Inferred from genetic interaction	33544780	MGI
acts upstream of or within L-ascorbic acid metabolic process	IMP IMP: Inferred from mutant phenotype	33544780	MGI
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	17234593	MGI
acts upstream of or within behavior	IGI IGI: Inferred from genetic interaction	22520507	MGI
acts upstream of or within behavior	IMP IMP: Inferred from mutant phenotype	21418141	MGI
acts upstream of or within blood circulation	IGI IGI: Inferred from genetic interaction	33544780	MGI
acts upstream of or within brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24342563	MGI
acts upstream of or within calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	22025725	MGI
acts upstream of or within carboxylic acid transport	IMP IMP: Inferred from mutant phenotype	33544780	MGI
involved in cardiac muscle contraction	IDA IDA: Inferred from direct assay	19376779	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	23527305	MGI
acts upstream of or within circadian rhythm	IGI IGI: Inferred from genetic interaction	22520507	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	23527305	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	30071271	MGI
acts upstream of or within fear response	IDA IDA: Inferred from direct assay	26463346	MGI
acts upstream of or within fear response	IMP IMP: Inferred from mutant phenotype	26463346	MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway	IMP IMP: Inferred from mutant phenotype	27549929	MGI
acts upstream of or within habituation	IMP IMP: Inferred from mutant phenotype	26501181	MGI
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	19376779	MGI
acts upstream of or within ionotropic glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17234593	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within locomotion	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	26501181	MGI
acts upstream of or within membrane depolarization	IMP IMP: Inferred from mutant phenotype	30819023	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	17234593	MGI
acts upstream of or within metabolic process	IMP IMP: Inferred from mutant phenotype	23527305	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within multicellular organism growth	IDA IDA: Inferred from direct assay	26463346	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	26463346	MGI
acts upstream of or within neurogenesis	IDA IDA: Inferred from direct assay	19666602	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	19666602	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	25523819	MGI
acts upstream of or within neuromuscular process controlling balance	IDA IDA: Inferred from direct assay	26463346	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22025725	MGI
acts upstream of or within pore complex assembly	IMP IMP: Inferred from mutant phenotype	23527305	MGI
involved in regulation of cardiac muscle cell membrane potential	IGI IGI: Inferred from genetic interaction	19376779	MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	25523819	MGI
acts upstream of or within response to acid chemical	IMP IMP: Inferred from mutant phenotype	22025725	MGI
acts upstream of or within response to activity	IMP IMP: Inferred from mutant phenotype	24342563	MGI
acts upstream of or within response to chemical	IMP IMP: Inferred from mutant phenotype	25523819	MGI
acts upstream of or within response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	25523819	MGI
acts upstream of or within response to environmental enrichment	IMP IMP: Inferred from mutant phenotype	26501181	MGI
acts upstream of or within response to hormone	IMP IMP: Inferred from mutant phenotype	24342563	MGI
acts upstream of or within response to immobilization stress	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within response to lithium ion	IMP IMP: Inferred from mutant phenotype	22025725	MGI
acts upstream of or within response to methamphetamine hydrochloride	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within response to monoamine	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within response to potassium ion	IMP IMP: Inferred from mutant phenotype	25523819	MGI
acts upstream of or within response to stress	IMP IMP: Inferred from mutant phenotype	21418141	MGI
acts upstream of or within response to temperature stimulus	IMP IMP: Inferred from mutant phenotype	20850480	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17234593	MGI
acts upstream of or within sleep	IMP IMP: Inferred from mutant phenotype	24342563	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	26501181	MGI
involved in sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	19376779	MGI
acts upstream of or within thalamus development	IMP IMP: Inferred from mutant phenotype	23527305	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	19666602	MGI
acts upstream of or within visual learning	IDA IDA: Inferred from direct assay	26463346	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	17234593	MGI
acts upstream of or within walking behavior	IMP IMP: Inferred from mutant phenotype	25523819	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell surface	IDA IDA: Inferred from direct assay	17804407	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10837135	MGI
located in neuron to neuron synapse	IDA IDA: Inferred from direct assay	21196491	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10837135	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	21196491	MGI
NOT located in plasma membrane	IDA IDA: Inferred from direct assay	10837135	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17804407	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	19376779	MGI
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	19376779	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/potassium-transporting ATPase subunit alpha-3

Na(+)/K(+) ATPase alpha(III) subunit	Na(+)/K(+) ATPase alpha-3 subunit
sodium pump subunit alpha-3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01188	ATP1B3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01184	ATP1A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp1a3	NCBI	NCBI:478

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