FMO5 - flavin containing dimethylaniline monoxygenase 5 Gene

Homo sapiens

Also known as hBVMO1

Gene ID: 2330 | Gene type: protein coding

About FMO5

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:147,184,305-147,227,284 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 5 paralogues. Biased expression in liver (RPKM 65.3), small intestine (RPKM 17.2) and 8 other tissues.

Summary

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the Enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

FMO5 Products(3)

mRNA	Protein	Name
NM_001144829.3	NP_001138301.1	flavin-containing monooxygenase 5 isoform 2
NM_001144830.3	NP_001138302.1	flavin-containing monooxygenase 5 isoform 3
NM_001461.4	NP_001452.2	flavin-containing monooxygenase 5 isoform 1

FMO5 Protein Structure

FMO-like

0
100
200
300
400
500
533 a.a.

Protein Preferred Names

Protein Names

flavin-containing monooxygenase 5

FMO 5

Related Diseases

Diseases

Alias

Trimethylaminuria

TMAU	Fish-Odor Syndrome
Fish Malodor Syndrome	Fish Odor Syndrome
Stale Fish Syndrome	Tmauria
Severe Primary Trimethylaminuria	Mesh
D008661	Fish Odour Syndrome

Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb

Chromosome 1q21.1 Deletion Syndrome	1q21.1 Microdeletion Syndrome
Monosomy 1q21.1	1q21.1 Microdeletion
Chromosome 1q21.1 Microdeletion Syndrome	1q21.1 Contiguous Gene Deletion
1q21.1 Deletion	Del(1)(Q21)
1q21.1 Deletion Syndrome

Duodenal Atresia

Duodenal Stenosis

Familial Duodenal Atresia

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05009	FMO5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FMO5	VGNC	VGNC:29053
Rattus norvegicus	FMO5	RGD	RGD:628602
Felis catus	FMO5	VGNC	VGNC:62311
Macaca mulatta	FMO5	VGNC	VGNC:72685
Mus musculus	FMO5	MGD	MGI:1310004
Canis familiaris	FMO5	VGNC	VGNC:40920