Ano5 - anoctamin 5 Gene

Also Known as Gdd1; Tmem16e; 9330162L24

Species: Mus musculus

Gene Type: protein coding
Gene ID: 233246

Summary

This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. Elevated levels of this protein were found in dystrophic mice. In humans, mutations of this gene are associated with with musculoskeletal disorders such as myopathies, muscular dystrophy and gnathodiaphyseal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Ano5 Products (2)

mRNA Protein Name
NM_001271879.1 NP_001258808.1 anoctamin-5 isoform 2
NM_177694.6 NP_808362.2 anoctamin-5 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
23532839 MGI
NOT enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
23532839 MGI
Cellular Component GO Annotation Evidence References Source
located in vesicle IDA
IDA: Inferred from direct assay
17418107 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

anoctamin-5

  • gnathodiaphyseal dysplasia 1 protein homolog

  • integral membrane protein GDD1

  • transmembrane protein 16E

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16253 Ano5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00745 ANO5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ano5 NCBI NCBI:203859