Picalm - phosphatidylinositol binding clathrin assembly protein Gene

Also Known as CALM; CLTH; fit1; fit-1; PAP180; mKIAA4114

Species: Mus musculus

Gene Type: protein coding

Gene ID: 233489

Summary

Predicted to enable several functions, including SH3 domain binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including amyloid-beta clearance by transcytosis; neuron projection morphogenesis; and regulation of amyloid precursor protein catabolic process. Located in clathrin-coated pit and vesicle. Colocalizes with perinuclear region of cytoplasm. Is expressed in several structures, including aorta; heart; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]

Picalm Products (7)

mRNA	Protein	Name
NM_001252520.2	NP_001239449.1	phosphatidylinositol-binding clathrin assembly protein isoform 2
NM_001252521.2	NP_001239450.1	phosphatidylinositol-binding clathrin assembly protein isoform 3
NM_001252522.2	NP_001239451.1	phosphatidylinositol-binding clathrin assembly protein isoform 4
NM_001252523.2	NP_001239452.1	phosphatidylinositol-binding clathrin assembly protein isoform 5
NM_001252524.2	NP_001239453.1	phosphatidylinositol-binding clathrin assembly protein isoform 6
NM_001360867.1	NP_001347796.1	phosphatidylinositol-binding clathrin assembly protein isoform 7
NM_146194.5	NP_666306.2	phosphatidylinositol-binding clathrin assembly protein isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance by transcytosis	IGI IGI: Inferred from genetic interaction	26005850	MGI
involved in amyloid-beta clearance by transcytosis	IMP IMP: Inferred from mutant phenotype	26005850	MGI
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	18842885	MGI
involved in clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	22539346	MGI
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	18842885	MGI
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	12832620	MGI
involved in learning or memory	IGI IGI: Inferred from genetic interaction	26005850	MGI
involved in positive regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	22539346	MGI
involved in positive regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	22539346	MGI
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	12832620	MGI
NOT involved in regulation of amyloid-beta formation	IGI IGI: Inferred from genetic interaction	26005850	MGI
involved in synaptic vesicle maturation	IMP IMP: Inferred from mutant phenotype	22851330	MGI
involved in vesicle cargo loading	IMP IMP: Inferred from mutant phenotype	22539346	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	12832620	MGI
colocalizes with perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18182011	MGI
located in vesicle	IDA IDA: Inferred from direct assay	22539346	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphatidylinositol-binding clathrin assembly protein	clathrin assembly lymphoid myeloid leukemia

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10478	PICALM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Picalm	NCBI	NCBI:8301