ANGEL1 - angel homolog 1 Gene

Also Known as Ccr4e; KIAA0759

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23357

About ANGEL1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:76,786,009-76,812,882 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 5 paralogues. Broad expression in testis (RPKM 25.2), spleen (RPKM 10.7) and 25 other tissues.

Summary

Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANGEL1 Products (4)

mRNA Protein Name
NM_001370746.1 NP_001357675.1 protein angel homolog 1 isoform 1 precursor
NM_001370747.1 NP_001357676.1 protein angel homolog 1 isoform 2 precursor
NM_001370748.1 NP_001357677.1 protein angel homolog 1 isoform 3 precursor
NM_015305.4 NP_056120.2 protein angel homolog 1 isoform 4 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables eukaryotic initiation factor 4E binding IDA
IDA: Inferred from direct assay
23814182 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31413325 GOA
enables protein domain specific binding IDA
IDA: Inferred from direct assay
23814182 GOA
Cellular Component GO Annotation Evidence References Source
located in cis-Golgi network IDA
IDA: Inferred from direct assay
23814182 GOA
located in cytosol IDA
IDA: Inferred from direct assay
23814182 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23814182 GOA
is active in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
36180430 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23814182 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
23814182 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGEL1 Protein Structure

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (248 - 619)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

protein angel homolog 1

Related Diseases

Diseases Alias
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9

  • Arrhythmogenic Right Ventricular Dysplasia 9

  • ARVD9

  • Arrhythmogenic Right Ventricular Cardiomyopathy 9

  • Arvc9

  • Familial Arrhythmogenic Right Ventricular Dysplasia 9

  • Dysplasia, Arrhythmogenic Right Ventricular, Type 9
Cranioectodermal Dysplasia 1

  • Sensenbrenner Syndrome

  • CED1

  • Levin Syndrome I

  • Cranio-Ectodermal Dysplasia

  • Dysplasia, Cranioectodermal, Type 1

  • Cranioectodermal Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00685 ANGEL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ANGEL1 VGNC VGNC:59778
Bos taurus ANGEL1 VGNC VGNC:25886
Macaca mulatta ANGEL1 VGNC VGNC:69639
Rattus norvegicus ANGEL1 RGD RGD:1306238
Canis familiaris ANGEL1 VGNC VGNC:37852
Mus musculus ANGEL1 MGD MGI:1915987
Others ANGEL1 NCBI