Dchs1 - dachsous cadherin related 1 Gene

Also Known as FIB1; CDH25; Gm165; PCDH16; 3110041P15Rik; C130033F22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 233651

Summary

Predicted to enable Cadherin binding activity and calcium ion binding activity. Involved in several processes, including cell migration; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and hippo signaling. Acts upstream of or within several processes, including animal organ development; condensed mesenchymal cell proliferation; and post-anal tail morphogenesis. Located in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; heart; hemolymphoid system gland; and lung. Used to study mitral valve prolapse. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Apr 2022]

Dchs1 Products (1)

mRNA Protein Name
NM_001162943.1 NP_001156415.1 protocadherin-16 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
26258302 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
21303848 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
26258302 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
26258302 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
26258302 MGI
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
26258302 MGI
acts upstream of or within cochlea development IMP
IMP: Inferred from mutant phenotype
21303848 MGI
acts upstream of or within condensed mesenchymal cell proliferation IGI
IGI: Inferred from genetic interaction
26116661 MGI
acts upstream of or within condensed mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
26116661 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
21303848 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
21303848 MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
19506035 MGI
involved in hippo signaling IMP
IMP: Inferred from mutant phenotype
24056717 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
21303848 MGI
acts upstream of or within mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
26258302 MGI
involved in mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
26258302 MGI
acts upstream of or within nephron development IGI
IGI: Inferred from genetic interaction
26116661 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
21303848 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
24056717 MGI
acts upstream of or within ossification involved in bone maturation IMP
IMP: Inferred from mutant phenotype
21303848 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
26258302 MGI
involved in pattern specification process IMP
IMP: Inferred from mutant phenotype
26258302 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
21303848 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
26258302 MGI
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
26258302 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
19506035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protocadherin-16

  • dachsous 1

  • protein Dchs1

  • protein dachsous homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03575 DCHS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20902 Dchs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27419 Dchs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dchs1 NCBI NCBI:8642