Mosmo - modulator of smoothened Gene

Also Known as Atthog

Species: Mus musculus

Gene Type: protein coding

Gene ID: 233812

Summary

Involved in negative regulation of smoothened signaling pathway; regulation of neuron differentiation; and regulation of protein stability. Located in Golgi apparatus and ciliary membrane. Orthologous to human MOSMO (modulator of smoothened). [provided by Alliance of Genome Resources, Apr 2022]

Mosmo Products (1)

mRNA	Protein	Name
NM_001164580.1	NP_001158052.1	modulator of smoothened protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	34486668	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	34486668	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	34486668	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	34486668	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	34486668	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	34486668	MGI
acts upstream of or within left/right pattern formation	IMP IMP: Inferred from mutant phenotype	34486668	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	34486668	MGI
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	29290584	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	34486668	MGI
involved in regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	29290584	MGI
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	29290584	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	34486668	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	29290584	MGI
located in ciliary membrane	IDA IDA: Inferred from direct assay	29290584	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	29290584	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
modulator of smoothened protein	Attenuator of Hedgehog uncharacterized protein C16orf52 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08599	MOSMO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mosmo	NCBI	NCBI:730094