AHCYL2 - adenosylhomocysteinase like 2 Gene

Also Known as IRBIT2; ADOHCYASE3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23382

About AHCYL2

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:129,225,030-129,430,211 (from NCBI)

This gene has 12 transcripts (splice variants), 287 orthologues and 2 paralogues. Broad expression in colon (RPKM 37.6), thyroid (RPKM 17.8) and 21 other tissues.

Summary

The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

AHCYL2 Products (9)

mRNA	Protein	Name
NM_001130720.3	NP_001124192.1	adenosylhomocysteinase 3 isoform b
NM_001130722.3	NP_001124194.2	adenosylhomocysteinase 3 isoform c
NM_001130723.3	NP_001124195.1	adenosylhomocysteinase 3 isoform d
NM_001393386.1	NP_001380315.1	adenosylhomocysteinase 3 isoform d
NM_001393387.1	NP_001380316.1	adenosylhomocysteinase 3 isoform e
NM_001393388.1	NP_001380317.1	adenosylhomocysteinase 3 isoform f
NM_001393389.1	NP_001380318.1	adenosylhomocysteinase 3 isoform f
NM_001393390.1	NP_001380319.1	adenosylhomocysteinase 3 isoform f
NM_015328.4	NP_056143.1	adenosylhomocysteinase 3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19220705	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHCYL2 Protein Structure

AdoHcyase

AdoHcyase_NAD

0
100
200
300
400
500
611 a.a.

Protein Preferred Names	Protein Names
adenosylhomocysteinase 3	IP(3)Rs binding protein released with IP(3) 2

Related Diseases

Diseases	Alias
Lacrimal Gland Carcinoma	Lacrimal Gland Cancer Carcinoma Of The Lacrimal Gland Malignant Neoplasm Of Lacrimal Gland Malignant Tumour Of Lacrimal Gland Neoplasm Of Lacrimal Gland Tumor Of The Lacrimal Gland Malignant Tumor Of Lacrimal Gland
Lacrimal Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Lacrimal Gland
Lacrimal Gland Adenocarcinoma	Adenocarcinoma Of Lacrimal Gland
Lacrimal System Cancer	Neoplasm Of Lacrimal System Lacrimal System Neoplasm Tumor Of The Lacrimal System
Mitochondrial Trifunctional Protein Deficiency	Tfp Deficiency MTPD Trifunctional Protein Deficiency Trifunctional Protein Deficiency With Myopathy And Neuropathy Tfpd Familial Hypertrophic Cardiomyopathy Cardiomyopathy Familial Hypertrophic Familial Hcm Heritable Hypertrophic Cardiomyopathy Mtp Deficiency Tpa Deficiency Trifunctional Protein Deficiency, Type 2 Abetalipoproteinemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00478	AHCYL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AHCYL2	RGD	RGD:1564895
Canis familiaris	AHCYL2	VGNC	VGNC:37726
Mus musculus	AHCYL2	MGD	MGI:1921590
Felis catus	AHCYL2	VGNC	VGNC:69343
Bos taurus	AHCYL2	VGNC	VGNC:25752
Macaca mulatta	AHCYL2	VGNC	VGNC:80771
Others	AHCYL2	NCBI