Tpcn2 - two pore segment channel 2 Gene

Also Known as Gm35086; D830047E22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 233979

Summary

Enables NAADP-sensitive calcium-release channel activity and voltage-gated Calcium Channel activity. Involved in several processes, including endocytosis involved in viral entry into host cell; endosome to lysosome transport of low-density lipoprotein particle; and release of sequestered calcium ion into cytosol. Located in lysosomal membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in pigmentation disease. Orthologous to human TPCN2 (two pore segment channel 2). [provided by Alliance of Genome Resources, Apr 2022]

Tpcn2 Products (1)

mRNA Protein Name
NM_146206.6 NP_666318.2 two pore channel protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAADP-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
19557428 MGI
enables NAADP-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
20495006 MGI
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
27231233 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
20495006 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
25144390 MGI
involved in endocytosis involved in viral entry into host cell IMP
IMP: Inferred from mutant phenotype
25722412 MGI
involved in endosome to lysosome transport of low-density lipoprotein particle IMP
IMP: Inferred from mutant phenotype
25144390 MGI
involved in intracellular pH reduction IDA
IDA: Inferred from direct assay
27231233 MGI
involved in negative regulation of developmental pigmentation IDA
IDA: Inferred from direct assay
27231233 MGI
involved in regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
32167471 MGI
involved in release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
20495006 MGI
involved in smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
20547763 MGI
Cellular Component GO Annotation Evidence References Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
19557428 MGI
located in lysosome IDA
IDA: Inferred from direct assay
20495006 MGI
located in melanosome membrane IDA
IDA: Inferred from direct assay
27231233 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

two pore channel protein 2

two pore calcium channel protein 2

  • voltage-dependent calcium channel protein TPC2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14927 TPCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpcn2 NCBI NCBI:219931