CELA3B - chymotrypsin like elastase 3B Gene

Also Known as CBPP; ELA3B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23436

About CELA3B

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:21,977,022-21,998,642 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 6 paralogues. Restricted expression toward pancreas (RPKM 10341.0).

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike Other elastases, Elastase 3B has little elastolytic activity. Like most of the human elastases, Elastase 3B is secreted from the pancreas as a zymogen and, like Other serine proteases such as trypsin, chymotrypsin and Kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of Cholesterol. Both Elastase 3A and Elastase 3B have been referred to as protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

CELA3B Products (1)

mRNA Protein Name
NM_007352.4 NP_031378.1 chymotrypsin-like elastase family member 3B preproprotein

CELA3B Protein Structure

Trypsin

Trypsin: Trypsin (29 - 263)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

chymotrypsin-like elastase family member 3B

  • cholesterol-binding pancreatic protease

Related Diseases

Diseases Alias
Exocrine Pancreatic Insufficiency
Pancreatic Steatorrhea

  • Pancreatic Steatorrhoea

  • Decreased Tolerance Of Pancreas

  • Pancreatic Disturbance Of Fat Absorption
Pancreatitis

  • Mumps Pancreatitis
Autoimmune Pancreatitis

  • Lymphoplasmocytic Sclerosing Pancreatitis

  • Aip
Common Bile Duct Disease

  • Common Bile Duct Diseases
Pancreatic Serous Cystadenoma
Acute Necrotizing Pancreatitis

  • Pancreatitis, Acute Necrotizing
Choledocholithiasis
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02458 CELA3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21104 Cela3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27623 Cela3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CELA3B RGD RGD:1307819