Ankle1 - ankyrin repeat and LEM domain containing 1 Gene

Also Known as Lem3; Ankrd41; C430003I23; 8430438L13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234396

Summary

Predicted to enable Endonuclease activity. Involved in negative regulation of mitotic recombination; regulation of lymphoid progenitor cell differentiation; and regulation of myeloid progenitor cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to colocalize with nucleus. Orthologous to human ANKLE1 (ankyrin repeat and LEM domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Ankle1 Products (2)

mRNA Protein Name
NM_001310502.1 NP_001297431.1 ankyrin repeat and LEM domain-containing protein 1 isoform 2
NM_172756.3 NP_766344.2 ankyrin repeat and LEM domain-containing protein 1 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
NOT involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
27010503 MGI
NOT involved in DNA repair IMP
IMP: Inferred from mutant phenotype
27010503 MGI
NOT involved in determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
27010503 MGI
NOT involved in erythrocyte maturation IMP
IMP: Inferred from mutant phenotype
27010503 MGI
involved in negative regulation of mitotic recombination IGI
IGI: Inferred from genetic interaction
27010503 MGI
NOT involved in regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
27010503 MGI
NOT involved in regulation of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
27010503 MGI
NOT involved in regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
27010503 MGI
involved in regulation of lymphoid progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
27010503 MGI
involved in regulation of myeloid progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
27010503 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ankyrin repeat and LEM domain-containing protein 1

  • LEM-domain containing 3

  • LEM-domain containing protein 3

  • ankyrin repeat domain 41

  • ankyrin repeat domain-containing protein 41

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00709 ANKLE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ankle1 NCBI NCBI:126549