Ankle1 - ankyrin repeat and LEM domain containing 1 Gene

Mus musculus

Also known as Lem3; Ankrd41; C430003I23; 8430438L13Rik

Gene ID: 234396 | Gene type: protein coding

About Ankle1

Summary

Predicted to enable Endonuclease activity. Involved in negative regulation of mitotic recombination; regulation of lymphoid progenitor cell differentiation; and regulation of myeloid progenitor cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to colocalize with nucleus. Orthologous to human ANKLE1 (ankyrin repeat and LEM domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Ankle1 Products(2)

mRNA	Protein	Name
NM_001310502.1	NP_001297431.1	ankyrin repeat and LEM domain-containing protein 1 isoform 2
NM_172756.3	NP_766344.2	ankyrin repeat and LEM domain-containing protein 1 isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27010503	MGI
NOT involved in DNA repair	IMP IMP: Inferred from mutant phenotype	27010503	MGI
NOT involved in determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	27010503	MGI
NOT involved in erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	27010503	MGI
involved in negative regulation of mitotic recombination	IGI IGI: Inferred from genetic interaction	27010503	MGI
NOT involved in regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	27010503	MGI
NOT involved in regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	27010503	MGI
NOT involved in regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	27010503	MGI
involved in regulation of lymphoid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	27010503	MGI
involved in regulation of myeloid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	27010503	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ankyrin repeat and LEM domain-containing protein 1

LEM-domain containing 3	LEM-domain containing protein 3
ankyrin repeat domain 41	ankyrin repeat domain-containing protein 41

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00709	ANKLE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ankle1	NCBI	NCBI:126549

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