Ces2c - carboxylesterase 2C Gene

Also Known as Ces2; CES 2; ACH M1; ces2A3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234671

Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and Cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. The transcription of this gene is regulated by several factors including HNF-4alpha (hepatocyte nuclear factor-4alpha), Sp1 (specificity protein 1), Sp3 and USF1 (upstream stimulatory factor 1). The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with several family members including a few of pseudogenes and Ces5 on chromosome 8.[provided by RefSeq, Jun 2010]

Ces2c Products (2)

mRNA Protein Name
NM_145603.2 NP_663578.1 acylcarnitine hydrolase precursor
NM_145603.2 NP_663578.1 acylcarnitine hydrolase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acylcarnitine hydrolase activity IDA
IDA: Inferred from direct assay
12859986 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within response to acid chemical IDA
IDA: Inferred from direct assay
16527247 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
12859986 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acylcarnitine hydrolase

  • acylcarnitine hydrolase M1

  • carboxylesterase 2

  • carboxylesterase ML3

  • carboxylic ester hydrolase

  • peroxisome proliferator-inducible acylcarnitine hydrolase

Recombinant Ces2c Proteins

Cat. No. Product Name Accession Purity
HY-P76193 CES2/carboxylesterase 2 Protein, Mouse (HEK293, His) Q91WG0 (Q27-K557) ≥ 90%, as determined by reducing SDS-PAGE.