Carmil2 - capping protein regulator and myosin 1 linker 2 Gene

Mus musculus

Also known as Gm585; Rltpr; CG1399-PB; D130029J02Rik

Gene ID: 234695 | Gene type: protein coding

About Carmil2

Summary

Predicted to enable phospholipid binding activity. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell activation; and positive regulation of cytokine production. Located in cell-cell junction; cytoplasm; and immunological synapse. Part of F-actin capping protein complex. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to human CARMIL2 (capping protein regulator and Myosin 1 linker 2). [provided by Alliance of Genome Resources, Apr 2022]

Carmil2 Products(1)

mRNA	Protein	Name
NM_001357333.1	NP_001344262.1	capping protein, Arp2/3 and myosin-I linker protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23793062	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23793062	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23793062	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	23793062	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	23793062	MGI
acts upstream of or within positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	24097820	MGI
acts upstream of or within positive regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	23793062	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	23793062	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	23793062	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of F-actin capping protein complex	IDA IDA: Inferred from direct assay	23793062	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	23793062	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	23793062	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

capping protein, Arp2/3 and myosin-I linker protein 2

F-actin-uncapping protein RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein	leucine-rich repeat-containing protein 16C

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01930	CARMIL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Carmil2	NCBI	NCBI:146206

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