ADAT1 - adenosine deaminase tRNA specific 1 Gene

Also Known as HADAT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23536

About ADAT1

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,596,868-75,623,281 (from NCBI)

This gene has 10 transcripts (splice variants), 196 orthologues and 14 paralogues. Ubiquitous expression in testis (RPKM 4.0), thyroid (RPKM 2.5) and 25 other tissues.

Summary

This gene is a member of the ADAR (Adenosine Deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific Adenosine Deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

ADAT1 Products (10)

mRNA Protein Name
NM_001324444.2 NP_001311373.1 tRNA-specific adenosine deaminase 1 isoform b
NM_001324445.2 NP_001311374.1 tRNA-specific adenosine deaminase 1 isoform a
NM_001324446.2 NP_001311375.1 tRNA-specific adenosine deaminase 1 isoform b
NM_001324448.2 NP_001311377.1 tRNA-specific adenosine deaminase 1 isoform c
NM_001324449.2 NP_001311378.1 tRNA-specific adenosine deaminase 1 isoform c
NM_001324450.2 NP_001311379.1 tRNA-specific adenosine deaminase 1 isoform d
NM_001324451.2 NP_001311380.1 tRNA-specific adenosine deaminase 1 isoform d
NM_001324452.2 NP_001311381.1 tRNA-specific adenosine deaminase 1 isoform e
NM_001324453.2 NP_001311382.1 tRNA-specific adenosine deaminase 1 isoform f
NM_012091.5 NP_036223.2 tRNA-specific adenosine deaminase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA binding IMP
IMP: Inferred from mutant phenotype
10430867 GOA
enables tRNA-specific adenosine deaminase activity IMP
IMP: Inferred from mutant phenotype
10430867 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA processing IMP
IMP: Inferred from mutant phenotype
10430867 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAT1 Protein Structure

A_deamin

A_deamin: Adenosine-deaminase (editase) domain (63 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

tRNA-specific adenosine deaminase 1

  • adenosine deaminase acting on tRNA

Related Diseases

Diseases Alias
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2

  • Hypophosphatemic Nephrolithiasis/Osteoporosis 2

  • NPHLOP2

  • Nephrolithiasis-Osteoporosis, Hypophosphatemic, 2

  • Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00320 ADAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22378 Adat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28902 Adat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADAT1 VGNC VGNC:37613
Felis catus ADAT1 VGNC VGNC:59608
Mus musculus ADAT1 MGD MGI:1353631
Bos taurus ADAT1 VGNC VGNC:25637
Macaca mulatta ADAT1 VGNC VGNC:69504
Rattus norvegicus ADAT1 RGD RGD:1591020
Others ADAT1 NCBI