2. Gene
  3. ADAT1 - adenosine deaminase tRNA specific 1 Gene

ADAT1 - adenosine deaminase tRNA specific 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HADAT1

Gene ID: 23536 | Gene type: protein coding

About ADAT1

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,596,868-75,623,281 (from NCBI)

This gene has 10 transcripts (splice variants), 196 orthologues and 14 paralogues. Ubiquitous expression in testis (RPKM 4.0), thyroid (RPKM 2.5) and 25 other tissues.

Summary

This gene is a member of the ADAR (Adenosine Deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific Adenosine Deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

ADAT1 Products(10)

mRNA Protein Name
NM_001324444.2 NP_001311373.1 tRNA-specific adenosine deaminase 1 isoform b
NM_001324445.2 NP_001311374.1 tRNA-specific adenosine deaminase 1 isoform a
NM_001324446.2 NP_001311375.1 tRNA-specific adenosine deaminase 1 isoform b
NM_001324448.2 NP_001311377.1 tRNA-specific adenosine deaminase 1 isoform c
NM_001324449.2 NP_001311378.1 tRNA-specific adenosine deaminase 1 isoform c
NM_001324450.2 NP_001311379.1 tRNA-specific adenosine deaminase 1 isoform d
NM_001324451.2 NP_001311380.1 tRNA-specific adenosine deaminase 1 isoform d
NM_001324452.2 NP_001311381.1 tRNA-specific adenosine deaminase 1 isoform e
NM_001324453.2 NP_001311382.1 tRNA-specific adenosine deaminase 1 isoform f
NM_012091.5 NP_036223.2 tRNA-specific adenosine deaminase 1 isoform a

ADAT1 Protein Structure

A_deamin

A_deamin: Adenosine-deaminase (editase) domain (63 - 497)

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  • 502 a.a.
Protein Preferred Names Protein Names

tRNA-specific adenosine deaminase 1

adenosine deaminase acting on tRNA

Related Diseases

Diseases Alias
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2

Hypophosphatemic Nephrolithiasis/Osteoporosis 2

NPHLOP2

Nephrolithiasis-Osteoporosis, Hypophosphatemic, 2

Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00320 ADAT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADAT1 VGNC VGNC:37613
Felis catus ADAT1 VGNC VGNC:59608
Mus musculus ADAT1 MGD MGI:1353631
Bos taurus ADAT1 VGNC VGNC:25637
Macaca mulatta ADAT1 VGNC VGNC:69504
Rattus norvegicus ADAT1 RGD RGD:1591020