SEC14L2 - SEC14 like lipid binding 2 Gene

Also Known as SPF; TAP; TAP1; C22orf6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23541

About SEC14L2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,397,018-30,425,303 (from NCBI)

This gene has 17 transcripts (splice variants), 201 orthologues and 6 paralogues. Biased expression in liver (RPKM 34.2), prostate (RPKM 20.5) and 7 other tissues.

Summary

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the Cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

SEC14L2 Products (4)

mRNA Protein Name
NM_001204204.3 NP_001191133.1 SEC14-like protein 2 isoform 3
NM_001291932.2 NP_001278861.1 SEC14-like protein 2 isoform 4
NM_012429.5 NP_036561.1 SEC14-like protein 2 isoform 1
NM_033382.3 NP_203740.1 SEC14-like protein 2 isoform 2

SEC14L2 Protein Structure

CRAL_TRIO_N

CRAL_TRIO_N: CRAL/TRIO, N-terminal domain (13 - 58)

CRAL_TRIO

CRAL_TRIO: CRAL/TRIO domain (79 - 244)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

SEC14-like protein 2

  • alpha-tocopherol-associated protein

SEC14L2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87068 SEC14L2 Antibody (YA6761) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Plica Syndrome

  • Synovitis
Ataxia With Vitamin E Deficiency

  • Ataxia With Isolated Vitamin E Deficiency

  • AVED

  • Familial Isolated Vitamin E Deficiency

  • Friedreich-Like Ataxia

  • Familial Isolated Deficiency Of Vitamin E

  • Isolated Vitamin E Deficiency

  • Ataxia, Friedreich-Like, With Selective Vitamin E Deficiency

  • Vitamin E Deficiency, Familial Isolated

  • Ved

  • Friedreich-Like Ataxia With Selective Vitamin E Deficiency

  • Five

  • Friedreich Ataxia Phenotype With Selective Vitamin E Deficiency

  • Vitamin E Familial Isolated, Deficiency Of

  • Ataxia Friedreich-Like With Selective Vitamin E Deficiency
Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To

  • Ornithine Carbamoyltransferase Deficiency

  • Ornithine Transcarbamylase Deficiency

  • Otc Deficiency

  • Ornithine Carbamoyltransferase Deficiency Disease

  • OTCD

  • Deficiency Of Citrulline Phosphorylase

  • Oct Deficiency

  • Hyperammonemia Due To Ornithine Carbamoyltransferase Deficiency

  • Deficiency, Ornithine Carbamoyltransferase
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12607 SEC14L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SEC14L2 VGNC VGNC:107721
Macaca mulatta SEC14L2 VGNC VGNC:108034
Mus musculus SEC14L2 MGD MGI:1915065
Rattus norvegicus SEC14L2 RGD RGD:621779
Others SEC14L2 NCBI