Cplx3 - complexin 3 Gene

Also Known as ERGL; CpxIII; Lamn1l; Lman1l; ERGIC-53L

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235415

Summary

Enables SNARE binding activity and neurotransmitter transmembrane transporter activity. Involved in Insulin secretion; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle exocytosis. Acts upstream of or within regulation of neurotransmitter secretion. Located in cytosol; photoreceptor ribbon synapse; and plasma membrane. Is anchored component of presynaptic active zone membrane and anchored component of synaptic vesicle membrane. Is expressed in cerebral cortex and cortical layer V. Orthologous to human CPLX3 (complexin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cplx3 Products (1)

mRNA Protein Name
NM_146223.3 NP_666335.1 complexin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
15911881 MGI
enables neurotransmitter transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
15911881 MGI
Biological Process GO Annotation Evidence References Source
involved in insulin secretion IMP
IMP: Inferred from mutant phenotype
15911881 MGI
acts upstream of or within regulation of neurotransmitter secretion IDA
IDA: Inferred from direct assay
15911881 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
IDA: Inferred from direct assay
27239031 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
27239031 MGI
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
15911881 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15911881 MGI
located in membrane IDA
IDA: Inferred from direct assay
15911881 MGI
NOT located in nucleus IDA
IDA: Inferred from direct assay
15911881 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
27239031 MGI
is active in photoreceptor ribbon synapse IMP
IMP: Inferred from mutant phenotype
27239031 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15911881 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
15911881 MGI
is active in presynaptic active zone membrane IEP
IEP: Inferred from expression pattern
15911881 MGI
is active in presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
15911881 MGI
located in synapse IDA
IDA: Inferred from direct assay
15911881 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
15911881 MGI
is active in synaptic vesicle membrane IEP
IEP: Inferred from expression pattern
15911881 MGI
is active in synaptic vesicle membrane IMP
IMP: Inferred from mutant phenotype
15911881 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complexin-3

  • CPX III

  • complexin III

  • lectin, mannose-binding, 1 like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03099 CPLX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20003 Cplx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26506 Cplx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cplx3 NCBI NCBI:594855