2. Gene
  3. Herc1 - HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Gene

Herc1 - HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as tbl; B230218H07; 2810449H11Rik; D130015N03Rik

Gene ID: 235439 | Gene type: protein coding

About Herc1

Summary

Acts upstream of or within negative regulation of autophagy; neuromuscular process controlling balance; and neuron differentiation. Is expressed in several structures, including jaw bone; nervous system; sensory organ; thymus primordium; and vibrissa. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein Ligase family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Herc1 Products(1)

mRNA Protein Name
NM_145617.3 NP_663592.3 probable E3 ubiquitin-protein ligase HERC1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of autophagy IMP
IMP: Inferred from mutant phenotype
20041218 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
29078390 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: Inferred from mutant phenotype
20041218 MGI
acts upstream of or within corpus callosum development IMP
IMP: Inferred from mutant phenotype
29078390 MGI
acts upstream of or within negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
20041218 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
20041218 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
7891151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable E3 ubiquitin-protein ligase HERC1

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06126 HERC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Herc1 NCBI NCBI:8925