SEZ6L - seizure related 6 homolog like Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23544

About SEZ6L

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:26,169,462-26,383,596 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 39 paralogues. Biased expression in brain (RPKM 35.1) and adrenal (RPKM 5.4).

Summary

Predicted to act upstream of or within adult locomotory behavior; nervous system development; and regulation of protein kinase C signaling. Predicted to be located in endoplasmic reticulum and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

SEZ6L Products (6)

mRNA Protein Name
NM_001184773.2 NP_001171702.1 seizure 6-like protein isoform 2 precursor
NM_001184774.2 NP_001171703.1 seizure 6-like protein isoform 3 precursor
NM_001184775.2 NP_001171704.1 seizure 6-like protein isoform 4 precursor
NM_001184776.2 NP_001171705.1 seizure 6-like protein isoform 5 precursor
NM_001184777.2 NP_001171706.1 seizure 6-like protein isoform 6 precursor
NM_021115.5 NP_066938.2 seizure 6-like protein isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEZ6L Protein Structure

CUB

CUB: CUB domain (281 - 386)

Sushi

Sushi: Sushi repeat (SCR repeat) (393 - 448)

CUB

CUB: CUB domain (452 - 559)

Sushi

Sushi: Sushi repeat (SCR repeat) (567 - 624)

CUB

CUB: CUB domain (628 - 722)

Sushi

Sushi: Sushi repeat (SCR repeat) (745 - 800)

Sushi

Sushi: Sushi repeat (SCR repeat) (806 - 865)

Sushi

Sushi: Sushi repeat (SCR repeat) (873 - 930)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1024 a.a.
Protein Preferred Names Protein Names

seizure 6-like protein

  • seizure related gene 6-like

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12754 SEZ6L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12755 SEZ6L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18545 Sez6l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19527 Sez6l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25027 Sez6l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26022 Sez6l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SEZ6L MGD MGI:1935121
Macaca mulatta SEZ6L VGNC VGNC:77176
Canis familiaris SEZ6L VGNC VGNC:46064
Felis catus SEZ6L VGNC VGNC:65050
Bos taurus SEZ6L VGNC VGNC:34503
Rattus norvegicus SEZ6L RGD RGD:1563628
Others SEZ6L NCBI