Slc17a5 - solute carrier family 17 (anion/sugar transporter), member 5 Gene

Mus musculus

Also known as SD; AST; NSD; SLD; ISSD; SIASD; SIALIN; 4732491M05; 4631416G20Rik

Gene ID: 235504 | Gene type: protein coding

About Slc17a5

Summary

Predicted to enable sialic acid transmembrane transporter activity. Acts upstream of or within response to bacterium. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including gut; liver; metanephros; nervous system; and sensory organ epithelium. Used to study lysosomal storage disease and sialuria. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a5 Products(2)

mRNA	Protein	Name
NM_001276452.1	NP_001263381.1	sialin isoform b
NM_172773.3	NP_766361.1	sialin isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucuronate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	10581036	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in neurotransmitter loading into synaptic vesicle	EXP EXP: Inferred from Experiment	18695252	MGI
involved in neurotransmitter loading into synaptic vesicle	IDA IDA: Inferred from direct assay	18695252	MGI
involved in neurotransmitter loading into synaptic vesicle	IEP IEP: Inferred from expression pattern	18695252	MGI
involved in neurotransmitter loading into synaptic vesicle	IMP IMP: Inferred from mutant phenotype	18695252	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15006695	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	18695252	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18695252	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	18695252	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18695252	MGI
is active in lysosomal membrane	IMP IMP: Inferred from mutant phenotype	10581036	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15006695	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	18695252	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sialin

H(+)/nitrate cotransporter	sodium/sialic acid cotransporter
vesicular H(+)/Aspartate-glutamate cotransporter

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13038	SLC17A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc17a5	NCBI	NCBI:26503

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