2. Gene
  3. PHLDA3 - pleckstrin homology like domain family A member 3 Gene

PHLDA3 - pleckstrin homology like domain family A member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TIH1

Gene ID: 23612 | Gene type: protein coding

About PHLDA3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,464,278-201,469,188 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 2 paralogues. Broad expression in fat (RPKM 24.2), esophagus (RPKM 11.1) and 22 other tissues.

Summary

Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PHLDA3 Products(1)

mRNA Protein Name
NM_012396.5 NP_036528.1 pleckstrin homology-like domain family A member 3
Protein Preferred Names Protein Names

pleckstrin homology-like domain family A member 3

TDAG51/Ipl homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10444 PHLDA3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PHLDA3 VGNC VGNC:106471
Mus musculus PHLDA3 MGD MGI:1351485
Felis catus PHLDA3 VGNC VGNC:107911
Bos taurus PHLDA3 VGNC VGNC:106865
Rattus norvegicus PHLDA3 RGD RGD:1310502