PHLDA3 - pleckstrin homology like domain family A member 3 Gene

Also Known as TIH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23612

About PHLDA3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,464,278-201,469,188 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 2 paralogues. Broad expression in fat (RPKM 24.2), esophagus (RPKM 11.1) and 22 other tissues.

Summary

Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PHLDA3 Products (1)

mRNA Protein Name
NM_012396.5 NP_036528.1 pleckstrin homology-like domain family A member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
19203586 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
19203586 GOA
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
19203586 GOA
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
19203586 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
19203586 GOA
enables phosphatidylinositol-5-phosphate binding IDA
IDA: Inferred from direct assay
19203586 GOA
Biological Process GO Annotation Evidence References Source
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: Inferred from direct assay
19203586 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
19203586 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
19203586 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19203586 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin homology-like domain family A member 3

  • TDAG51/Ipl homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10444 PHLDA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PHLDA3 VGNC VGNC:106471
Mus musculus PHLDA3 MGD MGI:1351485
Felis catus PHLDA3 VGNC VGNC:107911
Bos taurus PHLDA3 VGNC VGNC:106865
Rattus norvegicus PHLDA3 RGD RGD:1310502
Others PHLDA3 NCBI