Slc9a6 - solute carrier family 9 (sodium/hydrogen exchanger), member 6 Gene

Also Known as NHE6; mKIAA0267; 3732426M05; 6430520C02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 236794

Summary

Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Acts upstream of or within several processes, including brain-derived neurotrophic factor receptor signaling pathway; dendritic spine development; and regulation of neurotrophin Trk Receptor signaling pathway. Located in several cellular components, including axon; dendrite; and endosome. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Used to study Christianson syndrome. Human ortholog(s) of this gene implicated in Christianson syndrome. Orthologous to human SLC9A6 (solute carrier family 9 member A6). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a6 Products (2)

mRNA Protein Name
NM_001358861.1 NP_001345790.1 sodium/hydrogen exchanger 6 isoform 2
NM_172780.4 NP_766368.2 sodium/hydrogen exchanger 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables potassium:proton antiporter activity IDA
IDA: Inferred from direct assay
17005858 MGI
enables sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
17005858 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain-derived neurotrophic factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24035762 MGI
acts upstream of or within dendritic spine development IMP
IMP: Inferred from mutant phenotype
24035762 MGI
acts upstream of or within proton transmembrane transport IMP
IMP: Inferred from mutant phenotype
24035762 MGI
involved in regulation of intracellular pH IDA
IDA: Inferred from direct assay
17005858 MGI
acts upstream of or within regulation of neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24035762 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
EXP: Inferred from Experiment
31175985 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
31175985 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
31175985 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
24035762 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
31175985 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
31175985 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
31175985 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
23303939 MGI
located in axonal spine IDA
IDA: Inferred from direct assay
23303939 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
23303939 MGI
located in dendrite IDA
IDA: Inferred from direct assay
23303939 MGI
located in early endosome IDA
IDA: Inferred from direct assay
24035762 MGI
located in endosome IDA
IDA: Inferred from direct assay
24035762 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
31175985 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31175985 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
31175985 MGI
located in late endosome IDA
IDA: Inferred from direct assay
24035762 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17005858 MGI
located in recycling endosome IDA
IDA: Inferred from direct assay
23303939 MGI
located in synapse IDA
IDA: Inferred from direct assay
24035762 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13345 SLC9A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13346 SLC9A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc9a6 NCBI NCBI:10479