Slc9a6 - solute carrier family 9 (sodium/hydrogen exchanger), member 6 Gene

Mus musculus

Also known as NHE6; mKIAA0267; 3732426M05; 6430520C02Rik

Gene ID: 236794 | Gene type: protein coding

About Slc9a6

Summary

Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Acts upstream of or within several processes, including brain-derived neurotrophic factor receptor signaling pathway; dendritic spine development; and regulation of neurotrophin Trk Receptor signaling pathway. Located in several cellular components, including axon; dendrite; and endosome. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Used to study Christianson syndrome. Human ortholog(s) of this gene implicated in Christianson syndrome. Orthologous to human SLC9A6 (solute carrier family 9 member A6). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a6 Products(2)

mRNA	Protein	Name
NM_001358861.1	NP_001345790.1	sodium/hydrogen exchanger 6 isoform 2
NM_172780.4	NP_766368.2	sodium/hydrogen exchanger 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium:proton antiporter activity	IDA IDA: Inferred from direct assay	17005858	MGI
enables sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	17005858	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24035762	MGI
acts upstream of or within dendritic spine development	IMP IMP: Inferred from mutant phenotype	24035762	MGI
acts upstream of or within proton transmembrane transport	IMP IMP: Inferred from mutant phenotype	24035762	MGI
involved in regulation of intracellular pH	IDA IDA: Inferred from direct assay	17005858	MGI
acts upstream of or within regulation of neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24035762	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP EXP: Inferred from Experiment	31175985	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	31175985	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	31175985	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	24035762	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	31175985	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	31175985	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	31175985	MGI
located in axon terminus	IDA IDA: Inferred from direct assay	23303939	MGI
located in axonal spine	IDA IDA: Inferred from direct assay	23303939	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23303939	MGI
located in dendrite	IDA IDA: Inferred from direct assay	23303939	MGI
located in early endosome	IDA IDA: Inferred from direct assay	24035762	MGI
located in endosome	IDA IDA: Inferred from direct assay	24035762	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	31175985	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31175985	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	31175985	MGI
located in late endosome	IDA IDA: Inferred from direct assay	24035762	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17005858	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	23303939	MGI
located in synapse	IDA IDA: Inferred from direct assay	24035762	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/hydrogen exchanger 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13345	SLC9A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13346	SLC9A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc9a6	NCBI	NCBI:10479

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