Osbpl8 - oxysterol binding protein-like 8 Gene

Mus musculus

Also known as ORP-8; C730029P18Rik; D330025H14Rik

Gene ID: 237542 | Gene type: protein coding

About Osbpl8

Summary

This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Osbpl8 Products(2)

mRNA	Protein	Name
NM_001003717.1	NP_001003717.1	oxysterol-binding protein-related protein 8 isoform b
NM_175489.3	NP_780698.2	oxysterol-binding protein-related protein 8 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21441927	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21441927	MGI
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	23812417	MGI
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	23812417	MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21441927	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	21441927	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	23812417	MGI
acts upstream of or within protein localization to nuclear pore	IMP IMP: Inferred from mutant phenotype	21441927	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear membrane	IMP IMP: Inferred from mutant phenotype	22683860	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

oxysterol-binding protein-related protein 8

OSBP-related protein 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09845	OSBPL8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Osbpl8	NCBI	NCBI:114882

Name
Email *

	Sorry, but the email address you supplied was invalid.