2. Gene
  3. ARHGAP8 - Rho GTPase activating protein 8 Gene

ARHGAP8 - Rho GTPase activating protein 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP610; BPGAP1

Gene ID: 23779 | Gene type: protein coding

About ARHGAP8

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:44,752,575-44,862,784 (from NCBI)

This gene has 12 transcripts (splice variants), 167 orthologues and 1 paralogue. Broad expression in kidney (RPKM 6.0), thyroid (RPKM 5.9) and 18 other tissues.

Summary

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote ERK activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

ARHGAP8 Products(3)

mRNA Protein Name
NM_001017526.2 NP_001017526.1 rho GTPase-activating protein 8 isoform 1
NM_001198726.2 NP_001185655.1 rho GTPase-activating protein 8 isoform 3
NM_181335.3 NP_851852.2 rho GTPase-activating protein 8 isoform 2

ARHGAP8 Protein Structure

CRAL_TRIO_2

CRAL_TRIO_2: Divergent CRAL/TRIO domain (23 - 196)

RhoGAP

RhoGAP: RhoGAP domain (241 - 387)

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  • 464 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 8

BCH domain-containing Cdc42GAP-like protein

Related Diseases

Diseases Alias
Cerebellar Ataxia, Cayman Type

Cayman Type Cerebellar Ataxia

Ataxia, Cerebellar, Cayman Type

ATCAY

Cayman Cerebellar Ataxia

Cayman Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00941 ARHGAP8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARHGAP8 MGD MGI:1920417
Rattus norvegicus ARHGAP8 RGD RGD:1303143