ARHGAP8 - Rho GTPase activating protein 8 Gene

Also Known as PP610; BPGAP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23779

About ARHGAP8

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:44,752,575-44,862,784 (from NCBI)

This gene has 12 transcripts (splice variants), 167 orthologues and 1 paralogue. Broad expression in kidney (RPKM 6.0), thyroid (RPKM 5.9) and 18 other tissues.

Summary

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote ERK activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

ARHGAP8 Products (3)

mRNA	Protein	Name
NM_001017526.2	NP_001017526.1	rho GTPase-activating protein 8 isoform 1
NM_001198726.2	NP_001185655.1	rho GTPase-activating protein 8 isoform 3
NM_181335.3	NP_851852.2	rho GTPase-activating protein 8 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	20179103	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20179103	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20179103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP8 Protein Structure

CRAL_TRIO_2

RhoGAP

0
100
200
300
400
464 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 8	BCH domain-containing Cdc42GAP-like protein

Related Diseases

Diseases	Alias
Cerebellar Ataxia, Cayman Type	Cayman Type Cerebellar Ataxia Ataxia, Cerebellar, Cayman Type ATCAY Cayman Cerebellar Ataxia Cayman Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00941	ARHGAP8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARHGAP8	MGD	MGI:1920417
Rattus norvegicus	ARHGAP8	RGD	RGD:1303143