Atad5 - ATPase family, AAA domain containing 5 Gene

Also Known as Gm17; FRAG1; C130052G03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 237877

Summary

Predicted to enable DNA binding activity and DNA clamp unloader activity. Involved in cell population proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and nuclear DNA replication. Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Located in nucleus. Is expressed in liver; metanephros; midbrain ventricular layer; renal cortex; and telencephalon ventricular layer. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Atad5 Products (2)

mRNA Protein Name
NM_001029856.2 NP_001025027.1 ATPase family AAA domain-containing protein 5
NM_001029856.2 NP_001025027.1 ATPase family AAA domain-containing protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15983387 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
15983387 MGI
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of or within immunoglobulin production IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: Inferred from genetic interaction
15983387 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
IGI: Inferred from genetic interaction
15983387 MGI
acts upstream of isotype switching IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
15983387 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15983387 MGI
involved in nuclear DNA replication IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of nucleic acid metabolic process IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of or within positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of or within regulation of mitotic cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
25404367 MGI
acts upstream of or within signal transduction in response to DNA damage IMP
IMP: Inferred from mutant phenotype
15983387 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15983387 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATPase family AAA domain-containing protein 5

  • chromosome fragility associated gene 1

  • chromosome fragility-associated gene 1 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122198 ML367 Inhibitor 99.84% Unkown
HY-P10326 Z-ATAD-FMK Inhibitor / Unkown
HY-RS01123 ATAD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18987 Atad5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25476 Atad5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atad5 NCBI NCBI:79915