Sppl2c - signal peptide peptidase 2C Gene

Also Known as IMP5; 4933407P14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 237958

Summary

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi-associated vesicle membrane and lysosomal membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Orthologous to human SPPL2C (signal peptide peptidase like 2C). [provided by Alliance of Genome Resources, Apr 2022]

Sppl2c Products (2)

mRNA Protein Name
NM_001082535.1 NP_001076004.1 signal peptide peptidase-like 2C isoform b precursor
NM_199019.2 NP_950184.2 signal peptide peptidase-like 2C isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic endopeptidase activity, intramembrane cleaving IDA
IDA: Inferred from direct assay
30733280 MGI
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
30733280 MGI
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
35960805 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
35960805 MGI
Biological Process GO Annotation Evidence References Source
involved in acrosome assembly IDA
IDA: Inferred from direct assay
30733280 MGI
involved in fusion of sperm to egg plasma membrane involved in single fertilization IMP
IMP: Inferred from mutant phenotype
35960805 MGI
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
30733280 MGI
involved in membrane protein intracellular domain proteolysis IDA
IDA: Inferred from direct assay
30733281 MGI
involved in protein stabilization IDA
IDA: Inferred from direct assay
35960805 MGI
involved in spermatogenesis IDA
IDA: Inferred from direct assay
30733280 MGI
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30733280 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30733280 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal peptide peptidase-like 2C

  • IMP-5

  • SPP-like 2C

  • intramembrane protease 5

  • ortholog of human intramembrane protease 5 IMP5

  • protein SPP-like 2C

  • protein SPPL2c

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13706 SPPL2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sppl2c NCBI NCBI:162540