Aloxe3 - arachidonate lipoxygenase 3 Gene

Also Known as eLOX-3; e-LOX-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23801

Summary

Enables hepoxilin A3 synthase activity. Involved in several processes, including establishment of skin barrier; long-chain fatty acid metabolic process; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in epidermis. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOXE3 (arachidonate Lipoxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]

Aloxe3 Products (1)

mRNA	Protein	Name
NM_011786.2	NP_035916.2	hydroperoxide isomerase ALOXE3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables hepoxilin A3 synthase activity	IDA IDA: Inferred from direct assay	17045234	MGI
enables hepoxilin A3 synthase activity	IMP IMP: Inferred from mutant phenotype	22832496	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	17045234	MGI
NOT involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	22832496	MGI
acts upstream of or within ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	22832496	MGI
involved in ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	22832496	MGI
NOT involved in epidermis development	IMP IMP: Inferred from mutant phenotype	22832496	MGI
acts upstream of or within establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	22832496	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	22832496	MGI
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20530198	MGI
involved in hepoxilin biosynthetic process	IDA IDA: Inferred from direct assay	17045234	MGI
involved in hepoxilin biosynthetic process	IMP IMP: Inferred from mutant phenotype	22832496	MGI
involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	17045234	MGI
involved in peroxisome proliferator activated receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20530198	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hydroperoxide isomerase ALOXE3	epidermal LOX-3 epidermis-type lipoxygenase 3 hydroperoxy dehydratase ALOXE3 hydroperoxy icosatetraenoate dehydratase hydroperoxy icosatetraenoate isomerase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00626	ALOXE3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aloxe3	NCBI	NCBI:59344