Slc24a4 - solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Gene

Mus musculus

Also known as NCKX4; A930002M03Rik

Gene ID: 238384 | Gene type: protein coding

About Slc24a4

Summary

Enables calcium, potassium:sodium antiporter activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in several processes, including cellular response to high light intensity; cone photoresponse recovery; and ion transmembrane transport. Acts upstream of or within positive regulation of gene expression. Located in several cellular components, including cone photoreceptor outer segment; plasma membrane; and vesicle. Is active in apical plasma membrane. Is expressed in several structures, including central nervous system; eye; stomach; testis; and thymus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5. Orthologous to human SLC24A4 (solute carrier family 24 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc24a4 Products(2)

mRNA	Protein	Name
NM_001362345.2	NP_001349274.1	sodium/potassium/calcium exchanger 4 isoform 2
NM_172152.4	NP_742164.2	sodium/potassium/calcium exchanger 4 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium, potassium:sodium antiporter activity	IDA IDA: Inferred from direct assay	27093457	MGI
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	33199372	MGI
enables calmodulin binding	IPI IPI: Inferred from physical interaction	33199372	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in amelogenesis	IMP IMP: Inferred from mutant phenotype	23375655	MGI
involved in calcium ion export across plasma membrane	IDA IDA: Inferred from direct assay	33199372	MGI
involved in calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	25096581	MGI
involved in calcium ion import across plasma membrane	IDA IDA: Inferred from direct assay	27093457	MGI
involved in cellular response to high light intensity	IMP IMP: Inferred from mutant phenotype	28650316	MGI
involved in cone photoresponse recovery	IMP IMP: Inferred from mutant phenotype	28650316	MGI
involved in detection of chemical stimulus involved in sensory perception of smell	IMP IMP: Inferred from mutant phenotype	28053034	MGI
acts upstream of drinking behavior	IMP IMP: Inferred from mutant phenotype	25096581	MGI
involved in membrane repolarization	IMP IMP: Inferred from mutant phenotype	28053034	MGI
involved in negative regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	33199372	MGI
acts upstream of olfactory nerve maturation	IMP IMP: Inferred from mutant phenotype	28053034	MGI
acts upstream of phototransduction	IMP IMP: Inferred from mutant phenotype	28650316	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28053034	MGI
acts upstream of regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25096581	MGI
acts upstream of regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	25096581	MGI
acts upstream of response to melanocyte-stimulating hormone	IMP IMP: Inferred from mutant phenotype	25096581	MGI
involved in response to odorant	IMP IMP: Inferred from mutant phenotype	28053034	MGI
involved in sensory perception of smell	IMP IMP: Inferred from mutant phenotype	22057188	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	27752731	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	26403673	MGI
located in cone photoreceptor outer segment	IDA IDA: Inferred from direct assay	28650316	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	24621671	MGI
located in membrane	IDA IDA: Inferred from direct assay	24621671	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	26247047	MGI
located in vesicle	IDA IDA: Inferred from direct assay	33199372	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/potassium/calcium exchanger 4

K-dependent Na/Ca exchanger NCKX4	Na(+)/K(+)/Ca(2+)-exchange protein 4
solute carrier family 24 member 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13087	SLC24A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc24a4	NCBI	NCBI:123041

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