Slc24a4 - solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Gene

Also Known as NCKX4; A930002M03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 238384

Summary

Enables calcium, potassium:sodium antiporter activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in several processes, including cellular response to high light intensity; cone photoresponse recovery; and ion transmembrane transport. Acts upstream of or within positive regulation of gene expression. Located in several cellular components, including cone photoreceptor outer segment; plasma membrane; and vesicle. Is active in apical plasma membrane. Is expressed in several structures, including central nervous system; eye; stomach; testis; and thymus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5. Orthologous to human SLC24A4 (solute carrier family 24 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc24a4 Products (2)

mRNA Protein Name
NM_001362345.2 NP_001349274.1 sodium/potassium/calcium exchanger 4 isoform 2
NM_172152.4 NP_742164.2 sodium/potassium/calcium exchanger 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium, potassium:sodium antiporter activity IDA
IDA: Inferred from direct assay
27093457 MGI
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
33199372 MGI
enables calmodulin binding IPI
IPI: Inferred from physical interaction
33199372 MGI
Biological Process GO Annotation Evidence References Source
involved in amelogenesis IMP
IMP: Inferred from mutant phenotype
23375655 MGI
involved in calcium ion export across plasma membrane IDA
IDA: Inferred from direct assay
33199372 MGI
involved in calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
25096581 MGI
involved in calcium ion import across plasma membrane IDA
IDA: Inferred from direct assay
27093457 MGI
involved in cellular response to high light intensity IMP
IMP: Inferred from mutant phenotype
28650316 MGI
involved in cone photoresponse recovery IMP
IMP: Inferred from mutant phenotype
28650316 MGI
involved in detection of chemical stimulus involved in sensory perception of smell IMP
IMP: Inferred from mutant phenotype
28053034 MGI
acts upstream of drinking behavior IMP
IMP: Inferred from mutant phenotype
25096581 MGI
involved in membrane repolarization IMP
IMP: Inferred from mutant phenotype
28053034 MGI
involved in negative regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
33199372 MGI
acts upstream of olfactory nerve maturation IMP
IMP: Inferred from mutant phenotype
28053034 MGI
acts upstream of phototransduction IMP
IMP: Inferred from mutant phenotype
28650316 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28053034 MGI
acts upstream of regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25096581 MGI
acts upstream of regulation of eating behavior IMP
IMP: Inferred from mutant phenotype
25096581 MGI
acts upstream of response to melanocyte-stimulating hormone IMP
IMP: Inferred from mutant phenotype
25096581 MGI
involved in response to odorant IMP
IMP: Inferred from mutant phenotype
28053034 MGI
involved in sensory perception of smell IMP
IMP: Inferred from mutant phenotype
22057188 MGI
Cellular Component GO Annotation Evidence References Source
is active in apical plasma membrane IDA
IDA: Inferred from direct assay
27752731 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
26403673 MGI
located in cone photoreceptor outer segment IDA
IDA: Inferred from direct assay
28650316 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24621671 MGI
located in membrane IDA
IDA: Inferred from direct assay
24621671 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
26247047 MGI
located in vesicle IDA
IDA: Inferred from direct assay
33199372 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/potassium/calcium exchanger 4

  • K-dependent Na/Ca exchanger NCKX4

  • Na(+)/K(+)/Ca(2+)-exchange protein 4

  • solute carrier family 24 member 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13087 SLC24A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc24a4 NCBI NCBI:123041