Dido1 - death inducer-obliterator 1 Gene

Also Known as dido; DIO-1; Datf1; DATF-1; 6720461J16Rik; C130092D22Rik; D130048F08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23856

Summary

This gene encodes a transcription factor involved in Apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Dido1 Products (5)

mRNA Protein Name
NM_001291432.1 NP_001278361.1 death-inducer obliterator 1 isoform Dido1
NM_001291433.1 NP_001278362.1 death-inducer obliterator 1 isoform Dido2
NM_011805.3 NP_035935.2 death-inducer obliterator 1 isoform Dido1
NM_175551.4 NP_780760.2 death-inducer obliterator 1 isoform Dido3
NM_177852.4 NP_808520.2 death-inducer obliterator 1 isoform Dido2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10393935 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10393935 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

death-inducer obliterator 1

  • death inducer-obliterator-2

  • death inducer-obliterator-3

  • death-associated transcription factor 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101111 PF-06840003 Inhibitor 99.87% Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03767 DIDO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dido1 NCBI NCBI:11083