Dand5 - DAN domain family member 5, BMP antagonist Gene

Also Known as Dte; coco; Cerl2; Cerr2; GREM3; Cerl-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23863

Summary

Enables morphogen activity. Involved in determination of left/right asymmetry in lateral mesoderm; heart development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within determination of left/right symmetry and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in extracellular space. Is expressed in embryo; gut; node; and primitive streak. Orthologous to human DAND5 (DAN domain BMP antagonist family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Dand5 Products (1)

mRNA	Protein	Name
NM_201227.3	NP_957679.1	DAN domain family member 5 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables morphogen activity	IMP IMP: Inferred from mutant phenotype	15466485	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15466485	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in atrial septum development	IMP IMP: Inferred from mutant phenotype	15466485	MGI
involved in determination of heart left/right asymmetry	IMP IMP: Inferred from mutant phenotype	15466485	MGI
involved in determination of left/right asymmetry in lateral mesoderm	IMP IMP: Inferred from mutant phenotype	15466485	MGI
acts upstream of or within determination of left/right symmetry	IGI IGI: Inferred from genetic interaction	15466485	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15466485	MGI
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	15466485	MGI
involved in negative regulation of nodal signaling pathway	IDA IDA: Inferred from direct assay	15466485	MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	14721776	MGI
acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	10208746	MGI
involved in sequestering of nodal from receptor via nodal binding	IDA IDA: Inferred from direct assay	15466485	MGI
involved in ventricular septum development	IMP IMP: Inferred from mutant phenotype	15466485	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DAN domain family member 5	DAN domain family, member 5 cerberus-like protein 2 dante

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03522	DAND5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dand5	NCBI	NCBI:199699