Hs2st1 - heparan sulfate 2-O-sulfotransferase 1 Gene

Mus musculus

Also known as 2OST; Hs2st; mKIAA0448

Gene ID: 23908 | Gene type: protein coding

About Hs2st1

Summary

Enables heparan sulfate 2-O-sulfotransferase activity. Acts upstream of or within several processes, including heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin metabolic process; and ureteric bud formation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in brain and future brain. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hs2st1 Products(2)

mRNA	Protein	Name
NM_001355234.1	NP_001342163.1	heparan sulfate 2-O-sulfotransferase 1 isoform 1
NM_011828.4	NP_035958.3	heparan sulfate 2-O-sulfotransferase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparan sulfate 2-O-sulfotransferase activity	IDA IDA: Inferred from direct assay	15226404	MGI
enables heparan sulfate 2-O-sulfotransferase activity	IMP IMP: Inferred from mutant phenotype	11457822	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	32201365	MGI
involved in heparan sulfate proteoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	19889634	MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IMP IMP: Inferred from mutant phenotype	11457822	MGI
acts upstream of or within heparin metabolic process	IMP IMP: Inferred from mutant phenotype	11457822	MGI
acts upstream of or within ureteric bud formation	IMP IMP: Inferred from mutant phenotype	9637690	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	11687650	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heparan sulfate 2-O-sulfotransferase 1

2-O-sulfotransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06376	HS2ST1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hs2st1	NCBI	NCBI:9653

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