Lnpep - leucyl/cystinyl aminopeptidase Gene

Mus musculus

Also known as CAP; IRAP; PLAP; gp160; vp165; 2010309L07Rik; 4732490P18Rik

Gene ID: 240028 | Gene type: protein coding

About Lnpep

Summary

Enables Aminopeptidase activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within SMAD protein signal transduction and protein catabolic process. Located in cytoplasmic vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Is expressed in extraembryonic component; labyrinthine zone; and placenta. Orthologous to human LNPEP (leucyl and cystinyl Aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Lnpep Products(1)

mRNA	Protein	Name
NM_172827.3	NP_766415.1	leucyl-cystinyl aminopeptidase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	IMP IMP: Inferred from mutant phenotype	11884418	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15800058	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	25534853	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	11884418	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	12490950	MGI
located in membrane	IMP IMP: Inferred from mutant phenotype	11884418	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15800058	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15800058	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucyl-cystinyl aminopeptidase

OTase	cystinyl aminopeptidase
oxytocinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07730	LNPEP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lnpep	NCBI	NCBI:4012

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