Ldb3 - LIM domain binding 3 Gene

Also Known as ZASP; PDLIM6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24131

Summary

Enables muscle alpha-actinin binding activity and protein kinase C binding activity. Acts upstream of or within sarcomere organization. Located in Z disc. Is expressed in several structures, including central nervous system; heart; lower urinary tract; musculature; and sensory organ. Used to study congenital myopathy; dilated cardiomyopathy 1C; and myofibrillar myopathy 1. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to human LDB3 (LIM domain binding 3). [provided by Alliance of Genome Resources, Apr 2022]

Ldb3 Products (7)

mRNA Protein Name
NM_001039071.2 NP_001034160.1 LIM domain-binding protein 3 isoform b
NM_001039072.2 NP_001034161.1 LIM domain-binding protein 3 isoform c
NM_001039073.2 NP_001034162.1 LIM domain-binding protein 3 isoform d
NM_001039074.2 NP_001034163.1 LIM domain-binding protein 3 isoform e
NM_001039075.2 NP_001034164.1 LIM domain-binding protein 3 isoform f
NM_001039076.2 NP_001034165.1 LIM domain-binding protein 3 isoform g
NM_011918.4 NP_036048.3 LIM domain-binding protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables muscle alpha-actinin binding IDA
IDA: Inferred from direct assay
11696561 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10391924 MGI
enables protein kinase C binding IDA
IDA: Inferred from direct assay
10391924 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within sarcomere organization IMP
IMP: Inferred from mutant phenotype
11696561 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
16481394 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LIM domain-binding protein 3

  • PDZ-LIM domain protein

  • Z-band alternatively spliced PDZ-motif protein

  • cypher

  • oracle protein

  • protein cypher

  • protein oracle

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07570 LDB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ldb3 NCBI NCBI:11155