Crb2 - crumbs family member 2 Gene

Also Known as 5930402A21

Species: Mus musculus

Gene Type: protein coding

Gene ID: 241324

Summary

Predicted to enable aspartic-type endopeptidase inhibitor activity. Involved in several processes, including embryonic morphogenesis; maintenance of epithelial cell apical/basal polarity; and photoreceptor cell maintenance. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and cell junction. Part of subapical complex. Is expressed in early conceptus and embryo. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2). [provided by Alliance of Genome Resources, Apr 2022]

Crb2 Products (4)

mRNA	Protein	Name
NM_001163566.2	NP_001157038.1	protein crumbs homolog 2 isoform 1 precursor
NM_001413709.1	NP_001400638.1	protein crumbs homolog 2 isoform 2 precursor
NM_001163566.2	NP_001157038.1	protein crumbs homolog 2 isoform 1 precursor
NM_001413709.1	NP_001400638.1	protein crumbs homolog 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20399730	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in circulatory system development	IMP IMP: Inferred from mutant phenotype	22072575	MGI
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	23001562	MGI
involved in ingression involved in gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	27870829	MGI
involved in maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	22072575	MGI
involved in mesoderm formation	IMP IMP: Inferred from mutant phenotype	22072575	MGI
involved in notochord formation	IMP IMP: Inferred from mutant phenotype	22072575	MGI
involved in photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	23001562	MGI
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	22072575	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	22072575	MGI
involved in regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	26496195	MGI
involved in retina homeostasis	IMP IMP: Inferred from mutant phenotype	23001562	MGI
involved in retinal cone cell development	IMP IMP: Inferred from mutant phenotype	23001562	MGI
involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	22072575	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in apical part of cell	IDA IDA: Inferred from direct assay	25636444	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17920587	MGI
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	26404741	MGI
located in cell junction	IDA IDA: Inferred from direct assay	26404741	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	26404741	MGI
part of subapical complex	IDA IDA: Inferred from direct assay	16885194	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein crumbs homolog 2	crumbs homolog 2 crumbs-like protein 2 crumbs2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03141	CRB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crb2	NCBI	NCBI:286204