Calm3 - calmodulin 3 Gene

Also Known as Cam3; Camc; CaMIII; RNCAMIII

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24244

Summary

Enables several functions, including enzyme binding activity; nitric-oxide synthase regulator activity; and transmembrane transporter binding activity. Involved in several processes, including activation of Adenylate Cyclase activity; regulation of calcium ion transmembrane transporter activity; and regulation of vesicle-mediated transport. Located in several cellular components, including growth cone; myelin sheath; and nucleus. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human CALM3 (Calmodulin 3). [provided by Alliance of Genome Resources, Apr 2022]

Calm3 Products (1)

mRNA	Protein	Name
NM_012518.3	NP_036650.1	calmodulin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	15628869	RGD
enables nitric-oxide synthase binding	IDA IDA: Inferred from direct assay	20529840	RGD
enables nitric-oxide synthase regulator activity	IDA IDA: Inferred from direct assay	20529840	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11323678	RGD
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	15628869	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in establishment of protein localization to mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	20529840	RGD
involved in regulation of high voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	18322004	RGD
involved in regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	15628869	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	10854758	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	22848456	RGD
located in growth cone	IDA IDA: Inferred from direct assay	7492944	RGD
located in mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	19855925	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	22848456	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	22848456	RGD
located in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calmodulin-3	Calmodulin III caM

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01842	CALM3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Calm3	NCBI	NCBI:808