CALM3 - calmodulin 3 Gene

Also Known as CaM; CALM; CAM1; CAM2; CAMB; PHKD; CPVT6; LQT16; PHKD3; CaMIII; HEL-S-72

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 808

About CALM3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,601,074-46,610,782 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues, 20 paralogues and is associated with 5 phenotypes. Ubiquitous expression in brain (RPKM 470.4), testis (RPKM 108.1) and 23 other tissues.

Summary

This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]

CALM3 Products (7)

mRNA	Protein	Name
NM_001329921.1	NP_001316850.1	calmodulin-3 isoform 2
NM_001329922.1	NP_001316851.1	calmodulin-3 isoform 1
NM_001329923.1	NP_001316852.1	calmodulin-3 isoform 2
NM_001329924.2	NP_001316853.1	calmodulin-3 isoform 2
NM_001329925.2	NP_001316854.1	calmodulin-3 isoform 2
NM_001329926.2	NP_001316855.1	calmodulin-3 isoform 2
NM_005184.4	NP_005175.2	calmodulin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenylate cyclase activator activity	IDA IDA: Inferred from direct assay	11807546	GOA
enables adenylate cyclase binding	IPI IPI: Inferred from physical interaction	11807546	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	7607248	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	3111527	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables protein phosphatase activator activity	IDA IDA: Inferred from direct assay	8631777	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	35568036	GOA
enables titin binding	IPI IPI: Inferred from physical interaction	7607248	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21167176	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in detection of calcium ion	IMP IMP: Inferred from mutant phenotype	23040497	GOA
involved in negative regulation of high voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	31454269	GOA
involved in positive regulation of cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	8631777	GOA
involved in positive regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	20226167	GOA
involved in regulation of cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	31454269	GOA
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	23040497	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16760425	GOA
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	23040497	GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	20226167	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	7607248	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	23040497	GOA
part of catalytic complex	IDA IDA: Inferred from direct assay	11807546	GOA
located in centrosome	IDA IDA: Inferred from direct assay	16760425	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19855925	GOA
located in sarcomere	IDA IDA: Inferred from direct assay	20226167	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	16760425	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	16760425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALM3 Protein Structure

EF-hand_7

0
100
149 a.a.

Protein Preferred Names	Protein Names
calmodulin-3	Calmodulin-1

Recombinant CALM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7710	Calmodulin Protein, Human	P0DP23 (M1-K149)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75461	CALM2 Protein, Human (His)	P0DP24 (M1-K149)	≥ 95%, as determined by reducing SDS-PAGE.

CALM3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82082	Calmodulin Antibody (YA1827)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Long Qt Syndrome 16	Ventricular Tachycardia, Catecholaminergic Polymorphic, 6 LQT16 Ventricular Tachycardia, Catecholaminergic Polymorphic 6 CPVT6
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Catecholaminergic Polymorphic Ventricular Tachycardia	Cpvt Catecholamine-Induced Polymorphic Ventricular Tachycardia Familial Polymorphic Ventricular Tachycardia Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Stress-Induced Polymorphic Ventricular Tachycardia Bidirectional Tachycardia Induced By Catecholamine Double Tachycardia Induced By Catecholamines Polymorphic Catecholergic Ventricular Tachycardia Syncopal Paroxysmal Tachycardia Bidirectional Tachycardia Induced By Catecholamines Fpvt Bidirectional Ventricular Tachycardia Induced By Catecholamine Polymorphic Ventricular Tachycardia Induced By Catecholamines Ventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Familial Ventricular Tachycardia Multifocal Pvcs Multifocal Premature Ventricular Beats
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Long Qt Syndrome 14	LQT14 Long Qt Syndrome, Type 14
Long Qt Syndrome 15	LQT15 Long Qt Syndrome, Type 15
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Flying Phobia	Aerophobia
Medulloblastoma Shh Activated And Tp53 Mutant
Diamond-Blackfan Anemia 3	DBA3 Anemia, Diamond-Blackfan, 3 Rps24-Related Diamond-Blackfan Anemia Anemia Diamond-Blackfan 3 Anemia, Diamond-Blackfan, Type 3
Medulloblastoma Non-Wnt/Non-Shh
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01842	CALM3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CALM3	MGD	MGI:103249
Rattus norvegicus	CALM3	RGD	RGD:2259