CALM2 Protein, Human (His)

CALM2 (Calmodulin 2) serves as a critical component in calcium signal transduction pathways, playing a pivotal role in the regulation of numerous enzymes, ion channels, aquaporins, and other proteins through its calcium-binding capabilities. The activation of calmodulin is contingent upon calcium binding, enabling it to exert control over various cellular processes. Notably, the calmodulin-calcium complex stimulates a range of enzymes, including myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), as well as phosphatases. CALM2, in conjunction with CCP110 and centrin, participates in a genetic pathway that governs the centrosome cycle and progression through cytokinesis. Additionally, CALM2 mediates calcium-dependent inactivation of CACNA1C and positively regulates the calcium-activated potassium channel activity of KCNN2. Furthermore, in the context of microbial infection, CALM2 is required for the arginine ADP-ribosanase activity of C.violaceum CopC. These multifaceted functions underscore CALM2's integral role in orchestrating cellular responses to calcium signals. CALM2 Protein, Human (His) is the recombinant human-derived CALM2 protein, expressed by E. coli , with N-His labeled tag. The total length of CALM2 Protein, Human (His) is 149 a.a., with molecular weight of 19-22 kDa.

CALM2 (Calmodulin 2) serves as a critical component in calcium signal transduction pathways, playing a pivotal role in the regulation of numerous enzymes, ion channels, aquaporins, and other proteins through its calcium-binding capabilities. The activation of calmodulin is contingent upon calcium binding, enabling it to exert control over various cellular processes. Notably, the calmodulin-calcium complex stimulates a range of enzymes, including myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), as well as phosphatases. CALM2, in conjunction with CCP110 and centrin, participates in a genetic pathway that governs the centrosome cycle and progression through cytokinesis. Additionally, CALM2 mediates calcium-dependent inactivation of CACNA1C and positively regulates the calcium-activated potassium channel activity of KCNN2. Furthermore, in the context of microbial infection, CALM2 is required for the arginine ADP-ribosanase activity of C.violaceum CopC. These multifaceted functions underscore CALM2's integral role in orchestrating cellular responses to calcium signals.

Human

E. coli

N-His

P0DP24 (M1-K149)

801  [NCBI]

19-22 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.