CALM2 Protein, Human (His)
Based on 1 Customer Validation
The CALM2 protein is an important component of calcium signaling, controlling enzymes, ion channels, and aquaporins through calcium binding. CALM2 Protein, Human (His) is the recombinant human-derived CALM2 protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The CALM2 protein is an important component of calcium signaling, controlling enzymes, ion channels, and aquaporins through calcium binding. CALM2 Protein, Human (His) is the recombinant human-derived CALM2 protein, expressed by E. coli , with N-His labeled tag.
CALM2 (Calmodulin 2) serves as a critical component in calcium signal transduction pathways, playing a pivotal role in the regulation of numerous enzymes, ion channels, aquaporins, and other proteins through its calcium-binding capabilities. The activation of calmodulin is contingent upon calcium binding, enabling it to exert control over various cellular processes. Notably, the calmodulin-calcium complex stimulates a range of enzymes, including myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), as well as phosphatases. CALM2, in conjunction with CCP110 and centrin, participates in a genetic pathway that governs the centrosome cycle and progression through cytokinesis. Additionally, CALM2 mediates calcium-dependent inactivation of CACNA1C and positively regulates the calcium-activated potassium channel activity of KCNN2. Furthermore, in the context of microbial infection, CALM2 is required for the arginine ADP-ribosanase activity of C.violaceum CopC. These multifaceted functions underscore CALM2's integral role in orchestrating cellular responses to calcium signals.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-His
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Accession
P0DP24 (M1-K149)
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Molecular Construction
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N-term
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His
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CALM2 (M1-K149)
Accession # P0DP24 -
C-term
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Protein Length
Full Length
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Synonyms
CALM2; LP7057 Protein; Calmodulin 2; Calmodulin-1; PHKD2; Calmodulin-3; CAMII; CALML2; PHKD; CAMIII; Calmodulin 2 (Phosphorylase Kinase, Delta); LQT15; Phosphorylase Kinase Subunit Delta 2; CALM3; Phosphorylase Kinase Subunit Delta; CALM1; Prepro-Calmodul
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AA Sequence
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
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Molecular Weight
Approximately 19-22 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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