2. Gene
  3. Chd2 - chromodomain helicase DNA binding protein 2 Gene

Chd2 - chromodomain helicase DNA binding protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CHD-2; 2810013C04Rik; 2810040A01Rik; 5630401D06Rik

Gene ID: 244059 | Gene type: protein coding

About Chd2

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone binding activity. Involved in muscle organ development. Acts upstream of or within cellular response to DNA damage stimulus and hematopoietic stem cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study CHARGE syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human CHD2 (chromodomain helicase DNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Chd2 Products(1)

mRNA Protein Name
NM_001081345.2 NP_001074814.2 chromodomain-helicase-DNA-binding protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
22569126 MGI
enables histone binding IDA
IDA: Inferred from direct assay
22569126 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22569126 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
19137022 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
27783602 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
19137022 MGI
involved in muscle organ development IMP
IMP: Inferred from mutant phenotype
22569126 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
22569126 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromodomain-helicase-DNA-binding protein 2

ATP-dependent helicase CHD2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02607 CHD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04017 DSCAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chd2 NCBI NCBI:1106