2. Gene
  3. Erlin2 - ER lipid raft associated 2 Gene

Erlin2 - ER lipid raft associated 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Spfh2

Gene ID: 244373 | Gene type: protein coding

About Erlin2

Summary

Predicted to enable Cholesterol binding activity and ubiquitin protein Ligase binding activity. Predicted to be involved in SREBP signaling pathway; negative regulation of lipid biosynthetic process; and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within Cholesterol metabolic process. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and membrane raft. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18. Orthologous to human ERLIN2 (ER lipid raft associated 2). [provided by Alliance of Genome Resources, Apr 2022]

Erlin2 Products(10)

mRNA Protein Name
NM_001364476.1 NP_001351405.1 erlin-2 isoform 1
NM_001364477.1 NP_001351406.1 erlin-2 isoform 2
NM_001379175.1 NP_001366104.1 erlin-2 isoform 1
NM_001379176.1 NP_001366105.1 erlin-2 isoform 1
NM_001379177.1 NP_001366106.1 erlin-2 isoform 2
NM_001379178.1 NP_001366107.1 erlin-2 isoform 3
NM_001404114.1 NP_001391043.1 erlin-2 isoform 1
NM_001404115.1 NP_001391044.1 erlin-2 isoform 4
NM_001404116.1 NP_001391045.1 erlin-2 isoform 5
NM_153592.3 NP_705820.1 erlin-2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23884412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

erlin-2

SPFH domain family, member 2

SPFH domain-containing protein 2

endoplasmic reticulum lipid raft-associated protein 2

stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04502 ERLIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erlin2 NCBI NCBI:11160