2. Gene
  3. Sprtn - SprT-like N-terminal domain Gene

Sprtn - SprT-like N-terminal domain Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gm505

Gene ID: 244666 | Gene type: protein coding

About Sprtn

Summary

Predicted to enable several functions, including DNA binding activity; K63-linked polyubiquitin modification-dependent protein binding activity; and metalloendopeptidase activity. Involved in protein-DNA covalent cross-linking repair. Predicted to be located in chromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ruijs-Aalfs syndrome. Orthologous to human SPRTN (SprT-like N-terminal domain). [provided by Alliance of Genome Resources, Apr 2022]

Sprtn Products(1)

mRNA Protein Name
NM_001111141.2 NP_001104611.1 DNA-dependent metalloprotease SPRTN
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in protein-DNA covalent cross-linking repair IMP
IMP: Inferred from mutant phenotype
28199696 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-dependent metalloprotease SPRTN

sprT-like domain-containing protein Spartan

protein with SprT-like domain at the N terminus

spartan

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13720 SPRTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sprtn NCBI NCBI:83932