KCNJ1 - Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 Gene

Also Known as Kcnj; KAB-1; ROMK1; ROMK2; ROMK3; kir1.1; Kcnj1_v1; Kcnj1_v3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24521

Summary

Enables several functions, including ATP binding activity; ATP-activated inward rectifier Potassium Channel activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion transport; and response to potassium ion. Located in plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1). [provided by Alliance of Genome Resources, Apr 2022]

KCNJ1 Products (5)

mRNA Protein Name
NM_001309297.1 NP_001296226.1 ATP-sensitive inward rectifier potassium channel 1 isoform 2
NM_001309298.1 NP_001296227.1 ATP-sensitive inward rectifier potassium channel 1 isoform 3
NM_001309299.1 NP_001296228.1 ATP-sensitive inward rectifier potassium channel 1 isoform 3
NM_001309301.1 NP_001296230.1 ATP-sensitive inward rectifier potassium channel 1 isoform 3
NM_017023.2 NP_058719.2 ATP-sensitive inward rectifier potassium channel 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11956191 RGD
enables ATP-activated inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
7611454 RGD
enables inward rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
9015377 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
16906771 RGD
enables potassium ion binding IMP
IMP: Inferred from mutant phenotype
16906771 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to magnesium ion IDA
IDA: Inferred from direct assay
21030597 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22811560 RGD
involved in potassium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
9015377 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
11567030 RGD
involved in potassium ion transport IMP
IMP: Inferred from mutant phenotype
16906771 RGD
involved in response to potassium ion IEP
IEP: Inferred from expression pattern
20702602 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 1

  • ATP-regulated potassium channel ROM-K

  • K+ channel protein

  • inward rectifier K(+) channel Kir1.1

  • potassium channel, inwardly rectifying subfamily J member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5887 Tertiapin-RQ Inhibitor / Unkown
HY-RS07136 KCNJ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22587 Kcnj3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens KCNJ1 NCBI NCBI:3758