KCNJ1 - Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 Gene

Rattus norvegicus

Also known as Kcnj; KAB-1; ROMK1; ROMK2; ROMK3; kir1.1; Kcnj1_v1; Kcnj1_v3

Gene ID: 24521 | Gene type: protein coding

About KCNJ1

Summary

Enables several functions, including ATP binding activity; ATP-activated inward rectifier Potassium Channel activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion transport; and response to potassium ion. Located in plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1). [provided by Alliance of Genome Resources, Apr 2022]

KCNJ1 Products(5)

mRNA	Protein	Name
NM_001309297.1	NP_001296226.1	ATP-sensitive inward rectifier potassium channel 1 isoform 2
NM_001309298.1	NP_001296227.1	ATP-sensitive inward rectifier potassium channel 1 isoform 3
NM_001309299.1	NP_001296228.1	ATP-sensitive inward rectifier potassium channel 1 isoform 3
NM_001309301.1	NP_001296230.1	ATP-sensitive inward rectifier potassium channel 1 isoform 3
NM_017023.2	NP_058719.2	ATP-sensitive inward rectifier potassium channel 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11956191	RGD
enables ATP-activated inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	7611454	RGD
enables inward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	9015377	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	16906771	RGD
enables potassium ion binding	IMP IMP: Inferred from mutant phenotype	16906771	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to magnesium ion	IDA IDA: Inferred from direct assay	21030597	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22811560	RGD
involved in potassium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	9015377	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	11567030	RGD
involved in potassium ion transport	IMP IMP: Inferred from mutant phenotype	16906771	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	20702602	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 1

ATP-regulated potassium channel ROM-K	K+ channel protein
inward rectifier K(+) channel Kir1.1	potassium channel, inwardly rectifying subfamily J member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5887	Tertiapin-RQ	Inhibitor	/	Unkown
HY-RS07136	KCNJ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22587	Kcnj3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	KCNJ1	NCBI	NCBI:3758

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