2. Gene
  3. Mpz - myelin protein zero Gene

Mpz - myelin protein zero Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as P0; MPP

Gene ID: 24564 | Gene type: protein coding

About Mpz

Summary

This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I Transmembrane Glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]

Mpz Products(2)

mRNA Protein Name
NM_001314068.1 NP_001300997.1 myelin protein P0 isoform L-MPZ precursor
NM_017027.2 NP_058723.2 myelin protein P0 isoform MPZ precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20552241 RGD
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16788992 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
10212299 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin protein P0

myelin peripheral protein

myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08633 MPZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22082 Mpz Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpz NCBI NCBI:4359
Mus musculus Mpz NCBI NCBI:17528